EFFECTS OF ALPHA-LIPOIC ACID SUPPLEMENTATION ON DISEASE ACTIVITY AND INFLAMMATION IN RHEUMATOID ARTHRITIS PATIENTS: A RANDOMIZED PLACEBO-CONTROLLED TRIAL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

POURGHASEM GARGARI B.; MIRTAHERI E.; KOLAHI S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Nutrition and food in health and disease Year:2014 | Volume:1 | Issue:SUPPL. (1) Page(s): 210-210

Download Full-Text

View:

303

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF ALPHA-LIPOIC ACID SUPPLEMENTATION ON DISEASE ACTIVITY AND INFLAMMATION IN RHEUMATOID ARTHRITIS PATIENTS: A RANDOMIZED PLACEBO-CONTROLLED TRIAL

Author(s)

POURGHASEM GARGARI B. | MIRTAHERI E. | KOLAHI S.

Keywords

ALPHA-LIPOIC ACID

RHEUMATOID ARTHRITIS

INFLAMMATION

DISEASE ACTIVITY

Abstract

Background: ALPHA-LIPOIC ACID (ALA) has been considered as a potent antioxidant with anti-inflammatory functions in some oxidative stress-associated inflammatory diseases. However, few studies have evaluated its effects in RHEUMATOID ARTHRITIS (RA). Therefore, in the present study effects of ALA on DISEASE ACTIVITY and INFLAMMATION in women with RA was evaluated.Methods: This was a randomized, doubleblinded, placebo-controlled clinical trial.70 RA patients aged 20–50 years were randomly assigned to receive either ALA or placebo (1200 mg/day for 8 weeks). Before and after the study, fasting blood samples were taken from patients to analyze serum hs-CRP and TNF-a. Moreover, to evaluate the disease severity based on DISEASE ACTIVITY score in 28 joints (DAS-28), swollen and tender joints were examined by rheumatologist before and after the intervention period. Also, dietary intake and physical activity level were assessed respectively using three-day dietary record and international physical activity questionnaire at baseline and the end of the study.Results: 65 patients completed the study. Statistically significant differences in serum levels of hs-CRP, TNF-a and DAS-28 were not observed within and between the ALA and placebo groups (P>0.05). Also, dietary intakes and physical activity levels as confounding factors showed no significant inter- and intra-group changes (P>0.05).Conclusion: In the present study DISEASE ACTIVITY and INFLAMMATION were not significantly affected by 8 weeks of ALA supplementation. Further clinical trials with longer duration on patients with more active forms of RA are needed.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

POURGHASEM GARGARI, B., MIRTAHERI, E., & KOLAHI, S.. (2014). EFFECTS OF ALPHA-LIPOIC ACID SUPPLEMENTATION ON DISEASE ACTIVITY AND INFLAMMATION IN RHEUMATOID ARTHRITIS PATIENTS: A RANDOMIZED PLACEBO-CONTROLLED TRIAL. NUTRITION AND FOOD SCIENCES RESEARCH, 1(SUPPL. (1)), 210-210. SID. https://sid.ir/paper/342476/en

Vancouver: Copy

POURGHASEM GARGARI B., MIRTAHERI E., KOLAHI S.. EFFECTS OF ALPHA-LIPOIC ACID SUPPLEMENTATION ON DISEASE ACTIVITY AND INFLAMMATION IN RHEUMATOID ARTHRITIS PATIENTS: A RANDOMIZED PLACEBO-CONTROLLED TRIAL. NUTRITION AND FOOD SCIENCES RESEARCH[Internet]. 2014;1(SUPPL. (1)):210-210. Available from: https://sid.ir/paper/342476/en

IEEE: Copy

B. POURGHASEM GARGARI, E. MIRTAHERI, and S. KOLAHI, “EFFECTS OF ALPHA-LIPOIC ACID SUPPLEMENTATION ON DISEASE ACTIVITY AND INFLAMMATION IN RHEUMATOID ARTHRITIS PATIENTS: A RANDOMIZED PLACEBO-CONTROLLED TRIAL,” NUTRITION AND FOOD SCIENCES RESEARCH, vol. 1, no. SUPPL. (1), pp. 210–210, 2014, [Online]. Available: https://sid.ir/paper/342476/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops