Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   ACTA MEDICA IRANICA   2015 , Volume 53 , Number 1; Page(s) 8 To 16.
 
Paper: 

THE NEUROPROTECTIVE EFFECT OF A TRIAZINE DERIVATIVE IN AN ALZHEIMER’S RAT MODEL

 
 
Author(s):  ALIPOUR FATEMEH, ORYAN SHAHRBANOO, SHARIFZADEH MOHAMMAD, KARIMZADEH FARIBA, KAFAMI LAYA, IRANNEJAD HAMID, AMINI MOHSEN, HASSANZADEH GHOLAMREZA*
 
* DEPARTMENT OF ANATOMY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder. It is characterized by formation of amyloid plaques and neurofibrillary tangles in the brain, degeneration of the cholinergic neurons and neural cell death. This study was aimed to investigate the effect of a triazine derivative, C16H12Cl2N3S, on learning in an Alzheimer’s rat model. Animals were divided into seven groups; each group contained seven animals. Control group: animals received no surgery and treatment; saline group: animals received normal saline after recovery; sham group: animals received 10% DMSO after recovery; STZ group (Alzheimer’s model): animals received streptozotocin (STZ) in four and six days after recovery; T5, T10 and T15 groups: animals were treated with triazine derivative, C16H12Cl2N3S, at doses of 5, 10 and 15 mM, respectively. All drugs were injected intracerebroventricular. The spatial learning and histological assessment were performed in all groups. Animals in STZ group had more deficits in spatial learning than the control group in Morris water maze. C16H12Cl2N3S improved spatial learning significantly compared to STZ group. The CA1 pyramidal layer thicknesses in STZ group were reduced significantly compared to control group. C16H12Cl2N3S increased the CA1 pyramidal layer thickness in T15 group compared to STZ group. Current findings suggest C16H12Cl2N3S may have a protective effect on learning deficit and hippocampal structure in AD.
 
Keyword(s): TRIAZINE, LEARNING, ALZHEIMER’S DISEASE
 
 
References: 
 
Citations: 
 
+ Click to Cite.
APA: Copy

ALIPOUR, F., & ORYAN, S., & SHARIFZADEH, M., & KARIMZADEH, F., & KAFAMI, L., & IRANNEJAD, H., & AMINI, M., & HASSANZADEH, G. (2015). THE NEUROPROTECTIVE EFFECT OF A TRIAZINE DERIVATIVE IN AN ALZHEIMER’S RAT MODEL. ACTA MEDICA IRANICA, 53(1), 8-16. https://www.sid.ir/en/journal/ViewPaper.aspx?id=447276



Vancouver: Copy

ALIPOUR FATEMEH, ORYAN SHAHRBANOO, SHARIFZADEH MOHAMMAD, KARIMZADEH FARIBA, KAFAMI LAYA, IRANNEJAD HAMID, AMINI MOHSEN, HASSANZADEH GHOLAMREZA. THE NEUROPROTECTIVE EFFECT OF A TRIAZINE DERIVATIVE IN AN ALZHEIMER’S RAT MODEL. ACTA MEDICA IRANICA. 2015 [cited 2021December06];53(1):8-16. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=447276



IEEE: Copy

ALIPOUR, F., ORYAN, S., SHARIFZADEH, M., KARIMZADEH, F., KAFAMI, L., IRANNEJAD, H., AMINI, M., HASSANZADEH, G., 2015. THE NEUROPROTECTIVE EFFECT OF A TRIAZINE DERIVATIVE IN AN ALZHEIMER’S RAT MODEL. ACTA MEDICA IRANICA, [online] 53(1), pp.8-16. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=447276.



 
  pdf-File
Yearly Visit 82
 
 
Latest on Blog
Enter SID Blog