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Paper Information

Journal:   KOOMESH   Summer 2000 , Volume 1 , Number 3; Page(s) 47 To 52.
 
Paper: 

QUANTITATIVE AGE RELATED CHANGESS IN THE NUCLEUS RAPHE DORSALIS OF THE RAT

 
 
Author(s):  AMJAD M.H.T.*
 
* Dept. of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
 
Abstract: 

Introduction. About 50% of serotonergic neurons of the C.N.S exist in the dorsal raphe nucleus. To change the serotonin's rate of C.N.S induces many disorders. Due to age increase, morphologic changes in number and diameter of dendrites, number of their spines, number of fibers and cellular endings in the nucleus raphe dorsalis and rate of their staining are observed. The aim of this research is to survey of any changes in neurons numbers and volume of nucleus raphe dorsalis in aging.
Materials and Methods. In this research 15 female albino rats with age of 3 days, 2 and 12 months were used. The brain of these rats fixed by perfusion method with BOEIN solution, then the specimens stained by Cluver and Barrera method. The number of cells and volume of the nucleus raphe dorsalis have been calculated by using eye peace microscope. The data were analysed by Kraskul-Wallis test and P< 0.05 was considered as significant.
Results. Microscopic examinations have been shown that with increasing age the number of neurons of the nucleus raphe dorsalis and the volume of them significantly decreased (P<0.05).
Conclusion. These quantitative  changes in higher ages, make the negative effects in vital activity of the neurons, which may induce many disorders.

 
Keyword(s): NUCLEUS RAPHE DORSALIS, RETICULAR FORMATION, SEROTONERGIC SYSTEM, AGE RELATED CHANGES
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

AMJAD, M. (2000). QUANTITATIVE AGE RELATED CHANGESS IN THE NUCLEUS RAPHE DORSALIS OF THE RAT. KOOMESH, 1(3), 47-52. https://www.sid.ir/en/journal/ViewPaper.aspx?id=42803



Vancouver: Copy

AMJAD M.H.T.. QUANTITATIVE AGE RELATED CHANGESS IN THE NUCLEUS RAPHE DORSALIS OF THE RAT. KOOMESH. 2000 [cited 2021October20];1(3):47-52. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=42803



IEEE: Copy

AMJAD, M., 2000. QUANTITATIVE AGE RELATED CHANGESS IN THE NUCLEUS RAPHE DORSALIS OF THE RAT. KOOMESH, [online] 1(3), pp.47-52. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=42803.



 
 
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