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Paper Information

Journal:   ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)   Summer 2003 , Volume 5 , Number 2; Page(s) 145 To 150.
 
Paper: 

STUDY OF EFFECTS OF SEX AND BODY WEIGHT ON BASAL ACID SECRETION IN RAT

 
 
Author(s):  KOMEYLI GH.R., ZAHEDIASL S., GHARIB NASERI MOHAMMAD KAZEM
 
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Abstract: 

The amount of gastric acid secretion is not the same and changes during the time. May of the sex hormone effect on gastric acid secretion, all attempted were to use male animal in experiments. Because of different reports on basal acid output in rat (10 to 70 μmol/h), in present study was attempted to evaluate the effect of sex and body weight on basal acid output.

There was rats (n=51) range weight 140-370 g male and female was kept in temperature (23 ± 2 C) and light period. (12h light, 12h dark) Experiments were started in 8:00 AM, and 18 hours before experiment, animal were starved from food (except water). Animal’s anesthetized with Sodium thiopental, and a silicon tube was inserted in stomach via duodenum. The amount of acid was measured with aid of automatic acid titrator (TTT 80), with Na OH 0.1 N to pH=7. Using student t-Test and Spearman correlation coefficient compared the results (P<0.05).

In this study the mean of basal gastric acid secretion did not showed any difference between male and female. Means of the body and stomach weight were more in male (P<0.05), but the ratio of the stomach / body weight was bigger in female (P<0.05). In both male and female, basal acid output was correlated with body weight (r=0.4, P<0.01) and stomach weight (R=0.44, P<0.01).

However, it seems that is no difference in the mean of basal acid output between male and female rats. Despite of difference in body weight, there in no need to use only male animal in these kinds of experiments.

 
Keyword(s): BASAL ACID OUTPUT, SEX, BODY WEIGHT, RAT
 
References: 
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