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Paper Information

Journal:   MODARES MECHANICAL ENGINEERING   FEBRUARY 2015 , Volume 14 , Number 13; Page(s) 308 To 314.
 
Paper: 

RELATIONSHIP BETWEEN SPINAL FLUID AND CEREBROSPINAL FLUID AS AN INDEX FOR ASSESSMENT OF NON-COMMUNICATING HYDROCEPHALUS

 
 
Author(s):  GHOLAMPOUR SEIFOLLAH, SEDDIGHI AMIR SAEED, FATOURAEE NASSER*
 
* DEPARTMENT OF BIOMEDICAL ENGINEERING , AMIRKABIR UNIVERSITY OF TECHNOLOGY, TEHRAN, IRAN
 
Abstract: 

Occlusion of cerebrospinal fluid path increases the pressure exerted by the liquid on the walls of the ventricles and ultimately leads to hydrocephalus. This research investigated a numerical index to diagnose the non-communicating hydrocephalus disease. First, the diagram of velocity in Sylvius aqueduct of a healthy subject, obtained through a 3D FSI analysis was compared to a similar velocity diagram extracted from CINE-PC-MRI of the same subject. Then, after ensuring that the two diagrams coincide with each other, the problem assumptions and solution were confirmed. The Reynolds number in Sylvius aqueduct of a healthy subject was less than 275.7 and the maximum pressure of CSF was 616.3 Pa. Further, the conditions of ventricular system ina patient suffering from non-communicating hydrocephalus were modeled. The maximum pressure increased to 2958.5 Pa. Regarding the cause of hydrocephalus, the maximum pressure of CSF on the brain tissue in Sylvius aqueduct was introduced as an index to assess non-communicating hydrocephalus. Finally, calculated CSF pressure data of this study were compared to the data obtained through the lumber puncture (LP) test and it was found that these values are proportional to each other. Based on this finding, the CSF pressure obtained by LP test was introduced as a practical numerical index for diagnosis of non-communicating hydrocephalus.

 
Keyword(s): CEREBROSPINAL FLUID, LUMBER PUNCTURE, FLUID STRUCTURE INTERACTION, COMPUTATIONAL FLUID DYNAMICS
 
References: 
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