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Paper Information

Journal:   JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES   WINTER 2015 , Volume 16 , Number 4 (52); Page(s) 34 To 41.
 
Paper: 

EFFECT OF QUERCETIN ON LEARNING AND MEMORY IN STZ-INDUCED DIABETIC RAT

 
 
Author(s):  NASRI S.*, RAHIMI M., MOZAFARI M.
 
* DEPARTMENT OF BIOLOGY, PAYAMENOOR UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Background and Objective: Diabetes mellitus is common endocrine disease cause learning and memory impairment. This study was done to evaluate the effect of quercetin on learning and memory in STZinduced diabetic rats was investigated.
Methods: In this experimental study, 40 male Wistar rats were randomly allocated into five groups: control, quercetin - treated control, diabetic and quercetin - treated diabetic (10 and 20 mg/kg/bw, intraperitoneally) for 14 days. Induction of diabetes was performed using 60 mg/kg/bw of streptozotosin, interapritonally. Passive avoidance and Y-maze tests were used for the evaluation of learning and memory.
Results: In passive avoidance learning, there was no significant difference in initial latency between diabetic and treated - diabetic groups. The mean of step latency in control group (383.57
±19.26) significantly reduced to 128.86±10.38 in diabetic group (P<0.05). The mean of step latency in the treated diabetic group significantly increased in compare to the diabetic group (P<0.05). Step latency in quercetin - treated diabetic (10 mg/kg/bw) and (20 mg/kg/bw) groups increased to 316.67±23.76 and 397.50±31.21, respectively. The alternative percentage in diabetic group was significantly lower than control group (P<0.05), but in quercetin -treated diabetic groups it was higher than the diabetic group (P<0.05).
Conclusion: Administration of quercetin for 14 days enhances the capability of the memory storage, recall and improves short-term spatial memory in STZ-induced diabetic rats.

 
Keyword(s): DIABETES, QUERCETIN, LEARNING, MEMORY, RAT
 
References: 
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