Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES   MAY-JUNE 2014 , Volume 21 , Number 2; Page(s) 302 To 309.
 
Paper: 

THE EFFECT OF SALMETEROL ON SOME PARAMETERS OF PULMONARY VENTILATION IN SMOKERS AND NON- SMOKERS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

 
 
Author(s):  GOLMOHAMMADI R.*, NORI G.
 
* FACULTY OF MEDICINE, SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, SABZEVAR, IRAN
 
Abstract: 

Background: There are many factors that effect on the lungs capacity and treatment process in chronic obstructive pulmonary disease (COPD). Smoking, as a risk factor, is important in this process. The aim of this study was to evaluate the efficacy of Salmeterol on some parameters of pulmonary ventilation in smokers and non-smokers patients with COPD.
Materials and Methods: This desiccative analytical study was done on 117 patients with respiratory symptoms of COPD who had referred to an internist during 2010-2013 in Sabzevar city, Iran. Data collection methods include observation, clinical symptoms, and respiratory test (spirometry) that was performed by a physician. Before and after Salmeterol inhalation, pulmonary function tests were performed, and pulmonary parameters FEVI, FVC, FEV1% and PEF were measured and recorded. Data were analyzed using paired t test, and independent t test.
Results: Of 117 patients 75 (64%) were male and 42 (36%) were female. The mean age of smokers and non-smokers was 42.36±18.20 and 50.14±18.56, respectively; which was statistically significan (P<0.03). FEV1% was significantly different in COPD patients before and after Salmeterol inhalation (97.44±10.84 and 94.75±10.81, respectively) (P<0.04). In smokers, before Salmeterol inhalation, the mean forced expiratory volume in the first second (FEVI), was lower than nonsmokers, but after Salmeterol inhalation, was higher than nonsmokers, but not significant. Also, after Salmeterol inhalation, FEVI% was higher in non-smokers compared with smokers.
Conclusion: In smokers, COPD onset is 8 years earlier than non-smokers, and Salmeterol inhalation decreases FEVI% in COPD patients.

 
Keyword(s): SALMETEROL, COPD, CIGARETTE, LUNG, SMOKING
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 67
 
Latest on Blog
Enter SID Blog