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Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   MARCH 2014 , Volume 31 , Number 269 (SPECIAL ISSUE (SKIN DISEASES AND LEISHMANIASIS)); Page(s) 2257 To 2263.
 
Paper: 

COMPARING THE EFFECTS OF TOPICAL MILTEFOSINE AND GLUCANTIME IN TREATMENT OF CUTANEOUS LEISHMANIASIS

 
 
Author(s):  ASILIAN ALI, OMRANI SHAGHAYEGH, NILFOROUSHZADEH MOHAMMAD AIL*
 
* SKIN AND STEM CELL RESEARCH CENTER, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: Due to the limited number of studies, failure to adequately investigating the impact of miltefosine in the treatment of cutaneous leishmaniasis, and the fact that faster recovery of injuries causes less scarring for the patient, the present study aimed to investigate the effect of topical miltefosine on the treatment of cutaneous leishmaniasis.
Methods: In this clinical trial study, 64 patients with cutaneous leishmaniasis were equally treated in two groups with miltefosine and Glucantime. The first group of patients was treated with localized Glucantime 2 times a week (up to 28 days) and the second group was treated with localized miltefosine (ointment 6%), once daily (for 28 days), in a way that the lesion was completely smeared with the ointment. Patients were examined every week during treatment and the lesion size was recorded. All the patients’ lesions regarding their appearance, wound size, induration, erythema, and lesion size during weekly visits, at end of the treatment, and one month after the treatment were assessed.
Findings: Mean age of the patients was 23.12±13.30 years. The cure rate was 34.4% in patients treated with topical Glucantime, and 53.1% in the patients treated with topical miltefosine (P=0.010). 1 month after the treatment, the cure rate was 50% in patients treated with topical Glucantime, and 81.3% in patients treated with miltefosine (P=0.300). Mean size of the remaining scar caused by cutaneous leishmaniasis was 1.9 cm in the group treated with Glucantime, and 0.9 cm in the group treated with miltefosine (P=0.001).
Conclusion: According to the results of this study and other studies in this area, it can be concluded that topical miltefosine can treat the lesions faster than intralesional Glucantime injection. In addition, patients treated with topical miltefosine had smaller scars.

 
Keyword(s): GLUCANTIME, MILTEFOSINE, CUTANEOUS LEISHMANIASIS, TREATMENT
 
 
References: 
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Citations: 
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APA: Copy

ASILIAN, A., & OMRANI, S., & NILFOROUSHZADEH, M. (2014). COMPARING THE EFFECTS OF TOPICAL MILTEFOSINE AND GLUCANTIME IN TREATMENT OF CUTANEOUS LEISHMANIASIS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(269 (SPECIAL ISSUE (SKIN DISEASES AND LEISHMANIASIS))), 2257-2263. https://www.sid.ir/en/journal/ViewPaper.aspx?id=389365



Vancouver: Copy

ASILIAN ALI, OMRANI SHAGHAYEGH, NILFOROUSHZADEH MOHAMMAD AIL. COMPARING THE EFFECTS OF TOPICAL MILTEFOSINE AND GLUCANTIME IN TREATMENT OF CUTANEOUS LEISHMANIASIS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S). 2014 [cited 2021September26];31(269 (SPECIAL ISSUE (SKIN DISEASES AND LEISHMANIASIS))):2257-2263. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=389365



IEEE: Copy

ASILIAN, A., OMRANI, S., NILFOROUSHZADEH, M., 2014. COMPARING THE EFFECTS OF TOPICAL MILTEFOSINE AND GLUCANTIME IN TREATMENT OF CUTANEOUS LEISHMANIASIS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), [online] 31(269 (SPECIAL ISSUE (SKIN DISEASES AND LEISHMANIASIS))), pp.2257-2263. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=389365.



 
 
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