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Paper Information

Journal:   JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES   FALL 2013 , Volume 20 , Number 3; Page(s) 373 To 379.
 
Paper: 

ACUTE EFFECTS OF SWIMMING EXERCISE ON WITHDRAWAL SYNDROME SIGN IN MORPHINE-DEPENDENT RATS

 
 
Author(s):  JALALVAND A., HEIDARIANPOUR ALI*, ALMASI J.
 
* DEPARTMENT OF PHYSICAL EDUCATION AND SPORT SCIENCE, BU ALI SINA UNIVERSITY, HAMEDAN, IRAN
 
Abstract: 

Background: Aerobic exercise stimulates the release of b-endorphin and other endogenous opioid peptides that are induced influences of morphine and other receptors agonist’s opioid peptides. Therefore, it may be reduced withdrawal sign and benefit in withdrawal period.
The purpose of this study was investigated acute effects of swimming exercise on common behavior following withdrawal syndrome in morphine-dependent rats.
Method: in this experimental study Male Wistar rats (250
±20 g, N=24) in two group (control addiction, exercise trained addiction) were addicted by morphine sulfate 0.4 mg/ml (for 21 days) and animals were submitted to swimming training for 8 weeks; they initially swim 60 min for 3 weeks, then 90 min 2 weeks, finally 120 min for 3 weeks. At the end of each stage of exercise protocol we inject naloxan hydrochloride (3mg/kg.ip). Behavioral symptoms (such as jumping, tearing, teeth chattering, diarrhea, and body tremors) were measured based on 45-minute in addicted animal. Analysis of variance with repeated measures (with the software SPSS) was used to analyze the data.
Results: Our data showed that swimming exercise after 5 and 8 weeks acutely decreased withdrawal sign (p<0.05). Withdrawal sign did not significantly change after 3 weeks of swimming exercise in addicted rats.
Conclusion: Our data showed that swimming exercise after 8 weeks decreased Behavioral signs. Therefore, it can be used for the treatment and/or management of withdrawal conditions.

 
Keyword(s): SWIMMING EXERCISE, ADDICTION, WITHDRAWAL SYNDROME, MORPHINE SULFATE
 
References: 
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