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Paper Information

Journal:   IRANIAN JOURNAL OF PEDIATRICS   AUGUST 2013 , Volume 23 , Number 4; Page(s) 430 To 438.
 
Paper: 

COMBINATION OF PROBIOTICS AND ANTIBIOTICS IN THE PREVENTION OF RECURRENT URINARY TRACT INFECTION IN CHILDREN

 
 
Author(s):  MOHSENI MOHAMMAD JAVAD, ARYAN ZAHRA, EMAMZADEH FARD SAHRA, PAYDARY KOOSHA, MOFID VAHID, JOUDAKI HASAN, KAJBAFZADEH ABDOL MOHAMMAD*
 
* PEDIATRIC UROLOGY RESEARCH CENTER, PEDIATRIC CENTER OF EXCELLENCE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN (IRI)
 
Abstract: 
Objective: We examined the preventive effect of probiotic and antibiotics versus antibiotics alone, in children with recurrent urinary tract infections (RUTI) in a preliminary randomized clinical trial.Methods: Between March 2007 and April 2011, children with the history of RUTI and unilateral vesicoureteral reflux (VUR) were randomly assigned to receive concomitant probiotic and antibiotics (Lactobacillus acidophilus and bifidobacterium lactis, 107/ml, as 0.25 ml/kg three times a day regimen in addition to Nitrofurantoin, 1mg/kg daily (group I). In group II, all children received conventional prophylactic antibiotics alone (Nitrofurantoin, 1 mg/kg daily). Randomization was performed via using the random numerals table in a 1:1 manner with stratification by sex, age and grade of reflux. The urine examinations were done monthly and the incidence of UTI was evaluated in these two groups.Findings: Forty-one children (age: 8.3±3.1 years) in group I and 44 children (age: 8.0±3.0 years) in group II were compared. During the course of three years, 39% in group I and 50% of participants in group II experienced RUTIs (P=0.4). Incidences of UTI - febrile and afebrile - reduced in both groups without any significant differences after two years of prophylaxis. Also, incidence of afebrile UTIs did not significantly differ (0.51±1.30 and 0.81±1.41 respectively, P=0.3); however, the incidence of febrile UTIs in particular were lower in group I (0.00±0.00 versus 0.13±0.40, P=0.03) in the last year.Conclusion: The consumption of probiotic and antibiotics in children with RUTI is safe and more effective in reducing the incidence of febrile UTI in comparison to prophylactic antibiotics alone.
 
Keyword(s): LACTOBACILLUS ACIDOPHILUS, BIFIDOBACTERIUM LACTIS, ANTIBIOTIC PROPHYLAXIS, VESICOURETERAL REFLUX, URINARY TRACT INFECTION
 
 
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Citations: 
 
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APA: Copy

MOHSENI, M., & ARYAN, Z., & EMAMZADEH FARD, S., & PAYDARY, K., & MOFID, V., & JOUDAKI, H., & KAJBAFZADEH, A. (2013). COMBINATION OF PROBIOTICS AND ANTIBIOTICS IN THE PREVENTION OF RECURRENT URINARY TRACT INFECTION IN CHILDREN. IRANIAN JOURNAL OF PEDIATRICS, 23(4), 430-438. https://www.sid.ir/en/journal/ViewPaper.aspx?id=367579



Vancouver: Copy

MOHSENI MOHAMMAD JAVAD, ARYAN ZAHRA, EMAMZADEH FARD SAHRA, PAYDARY KOOSHA, MOFID VAHID, JOUDAKI HASAN, KAJBAFZADEH ABDOL MOHAMMAD. COMBINATION OF PROBIOTICS AND ANTIBIOTICS IN THE PREVENTION OF RECURRENT URINARY TRACT INFECTION IN CHILDREN. IRANIAN JOURNAL OF PEDIATRICS. 2013 [cited 2021December04];23(4):430-438. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=367579



IEEE: Copy

MOHSENI, M., ARYAN, Z., EMAMZADEH FARD, S., PAYDARY, K., MOFID, V., JOUDAKI, H., KAJBAFZADEH, A., 2013. COMBINATION OF PROBIOTICS AND ANTIBIOTICS IN THE PREVENTION OF RECURRENT URINARY TRACT INFECTION IN CHILDREN. IRANIAN JOURNAL OF PEDIATRICS, [online] 23(4), pp.430-438. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=367579.



 
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