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Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2003 , Volume 8 , Number 3 (33); Page(s) 219 To 226.
 
Paper: 

SURVEYING THE PHAGOCYTIC ACTIVITY OF MACROPHAGES USING PMA AND EVALUATION OF FREE RADICALS

 
 
Author(s):  MOSAFA NARIMAN*, NESHATIAN L.
 
* Department of Immunology, Shaheed Beheshti University of Medical Sciences
 
Abstract: 

Background: Macrophages are a group of mononuclear leukocytes that differed widely in phenotype and duration of life. During phagocytosis a metabolic process is occurred in activated macrophages that could be evaluated by NBT test. We have evaluated the effects of PMA on maturation and development of monocytes and their transformation to macrophages.
Materials and methods: During this experimental study, development and adhesion of monocytes and their transformation to macrophages was first assessed, then, metabolic process in activated macrophages was ealuated using NBT test.
Results: Having stimulated with PMA, monocytes showed adhesion capability during the second and third hours, however, after that they revealed to be decreased in number due to apoptosis. Meanwhile, cellular viabiligy was higher in nonstimulated group with PMA since PMA showed to have an apoptotic effect.
Conclusion: PMA could stimulate monocytic-macrophagic systems. Further studies on human beings are highly recommended.

 
Keyword(s): MACROPHAGE, PHAGOCYTIC ACTIVITY, PMA
 
 
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Citations: 
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APA: Copy

MOSAFA, N., & NESHATIAN, L. (2003). SURVEYING THE PHAGOCYTIC ACTIVITY OF MACROPHAGES USING PMA AND EVALUATION OF FREE RADICALS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 8(3 (33)), 219-226. https://www.sid.ir/en/journal/ViewPaper.aspx?id=3607



Vancouver: Copy

MOSAFA NARIMAN, NESHATIAN L.. SURVEYING THE PHAGOCYTIC ACTIVITY OF MACROPHAGES USING PMA AND EVALUATION OF FREE RADICALS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH). 2003 [cited 2021October27];8(3 (33)):219-226. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=3607



IEEE: Copy

MOSAFA, N., NESHATIAN, L., 2003. SURVEYING THE PHAGOCYTIC ACTIVITY OF MACROPHAGES USING PMA AND EVALUATION OF FREE RADICALS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), [online] 8(3 (33)), pp.219-226. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=3607.



 
 
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