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Paper Information

Journal:   MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES   JUNE-JULY 2013 , Volume 35 , Number 2; Page(s) 38 To 43.
 
Paper: 

ASSOCIATION OF 137 POLYMORPHISM IN THE INTERLEUKIN-18 GENE PROMOTER WITH DIABETES MELHITUS TYPE 1 IN EAST AZERBAIJAN POPULATION

 
 
Author(s):  RAHBANI NABAR MOHAMMAD*, REZAIE ALI, BAZZAZ SATTAR, AGHAMOHAMMAD ZADEH NASER
 
* DEPARTMENT OF BIOLOGICAL SCIENCE, AHAR BRANCH, ISLAMIC AZAD UNIVERSITY AHAR, IRAN
 
Abstract: 

Background and Objectives: Interleukin-18 (IL-18) plays a key role in autoimmunity, inflammation and infection diseases and its higher levels are reported during the subclinical stage of type 1 diabetes mellitus. The aim of this study was to evaluate the recently described single-nucleotide-polymorphisms of promoter of IL-18 gene at position-137, in type 1 diabetic patients, which has been suggested to cause differences in transcription factor binding and IL-18 gene activity.
Material and Methods: In this study, 104 type 1 diabetic patients (33female and 71 male) with mean age of 19.6
±10.4 years, and 92 ages and sex matched, healthy individuals without family history of diabetes and autoimmune diseases were selected as controls. The single- nucleotide-polymorphism (SNP) at position-137 (G/C) in the promoter region of IL-18 gene was analyzed by sequence-specific PCR.
Results: The genotype distribution differed significantly between patient and controls (p=0.038). The difference reflected as an increase in The GG genotypes at position-137 in promoter of IL-18 gene.
Conclusion: The results of these studies suggest an association between type 1 diabetes and polymorphisms in the promoter region of IL-18.

 
Keyword(s): IL-18, POLYMORPHISM, TYPE 1 DIABETES MELLITUS
 
References: 
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