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Paper Information

Journal:   DARU JOURNAL OF PHARMACEUTICAL SCIENCE   2004 , Volume 12 , Number 1; Page(s) 44 To 48.
 
Paper: 

THE ANTI-METASTATIC POTENCY OF GNIDILATIMONOEIN, FROM DAPHNE MUCRONATA, COMPARED TO TWO GLYCOSYLATION INHIBITORS: CASTANOSPERMINE AND TUNICAMYCI

 
 
Author(s):  MIANABADI M., YAZDANPARAS R.*
 
* INST. BIOCHEMISTRY-BIOPHYSIC, UNIVERSITY OF TEHRAN, TEHRAN, IRAN
 
Abstract: 
fiogf49gjkf0dIt is well known that the modification of oligosaccharide moieties of the cell surface glycoproteins modulates the adhesion and metastatic potential of several cancerous cell lines. Based on this knowledge, the anti-metastatic property of Daphne mucronata crude extract and one of its newly characterized active component, Gnidilatimonoein, were evaluated in wehi-164 cells by measuring their adhesion to fibronectin coated plates, relative to Castanospermine and Tunicamycin treated cells.Twenty four hours after treatment of the cells with the plant crude extract (equivalent to 0.54 mg of the plant leaves powder/ml), Gnidilatimonoein (0.94 nM), Castanospermine (2.6 µM) and/or Tunicamycin (2.4 µM), their attachment to fibronectin-coated wells were depressed, by 24%, 30%, 26% and 58%, respectively. This data may classify the new anticancer compound, Gnidilatimonoein, as a strong glycosylation inhibitor.
 
Keyword(s): ADHESION, DAPHNE MUCRONATA, GLYCOSYLATION INHIBITOR, GNIDILATIMONOEIN
 
 
References: 
 
Citations: 
 
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APA: Copy

MIANABADI, M., & YAZDANPARAS, R. (2004). THE ANTI-METASTATIC POTENCY OF GNIDILATIMONOEIN, FROM DAPHNE MUCRONATA, COMPARED TO TWO GLYCOSYLATION INHIBITORS: CASTANOSPERMINE AND TUNICAMYCI. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 12(1), 44-48. https://www.sid.ir/en/journal/ViewPaper.aspx?id=34231



Vancouver: Copy

MIANABADI M., YAZDANPARAS R.. THE ANTI-METASTATIC POTENCY OF GNIDILATIMONOEIN, FROM DAPHNE MUCRONATA, COMPARED TO TWO GLYCOSYLATION INHIBITORS: CASTANOSPERMINE AND TUNICAMYCI. DARU JOURNAL OF PHARMACEUTICAL SCIENCE. 2004 [cited 2021December04];12(1):44-48. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=34231



IEEE: Copy

MIANABADI, M., YAZDANPARAS, R., 2004. THE ANTI-METASTATIC POTENCY OF GNIDILATIMONOEIN, FROM DAPHNE MUCRONATA, COMPARED TO TWO GLYCOSYLATION INHIBITORS: CASTANOSPERMINE AND TUNICAMYCI. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, [online] 12(1), pp.44-48. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=34231.



 
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