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Paper Information

Journal:   DARU JOURNAL OF PHARMACEUTICAL SCIENCE   MARCH 2013 , Volume 21 , Number 3; Page(s) 0 To 0.
 
Paper: 

A CYTOTOXIC HYDROPEROXY STEROL FROM THE BROWN ALGA, NIZAMUDDINIA ZANARDINII

 
 
Author(s):  HAMZELOO MOGHADAM MARYAM, FIROUZI JAMILEH, SAEIDNIA SOODABEH, HAJIMEHDIPOOR HOMA, JAMILI SHAHLA, RUSTAIYAN ABDOLHOSSEIN, GOHARI AHMAD R.*
 
* MEDICINAL PLANTS RESEARCH CENTER, FACULTY OF PHARMACY, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: The marine environment is a unique source of bioactive natural products, of which Nizamuddinia zanardinii is an important brown algae distributed in Oman Sea. Literature revealed that there is no report on phytochemistry and pharmacology of this valuable algae.
Methods: Bioguided fractionation of the methanolic extract of Nizamuddinia zanardinii, collected from Oman Sea, led to the isolation of a hydroperoxy sterol. Its structure was determined by analysis of the spectroscopic data as 24-hydroperoxy-24-vinyl cholesterol (HVC). In vitro cytotoxic activity of this compound was evaluated against HT29, MCF7, A549, HepG2 and MDBK cell lines.
Results: Although 24 (R) -hydroproxy-24-vinylcholesterol has been previously reported from Sargassum and Padina species, it is the first report on the presence of this compound from N. zanardinii. This compound exhibited cytotoxicity in all cell lines (IC50, 3.62, 9.09, 17.96, 32.31 and 37.31
mg/mL respectively). HVC was also evaluated for apoptotic activity and demonstrated positive results in terminal deoxynucleotidyl transferase dUTP Nick End labeling (TUNEL) assay suggesting it a candidate for further apoptotic studies.
Conclusions: Nizamuddinia zanardinii, a remarkable brown algae of Oman Sea, is a good source of hydroproxy sterols with promising cytotoxic on various cell lines particularly human colon adenocarcinoma.

 
Keyword(s): NIZAMUDDINIA ZANARDINII, BROWN ALGAE, STEROL, MTT ASSAY, TUNEL, APOPTOSIS
 
 
References: 
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Citations: 
 
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APA: Copy

HAMZELOO MOGHADAM, M., & FIROUZI, J., & SAEIDNIA, S., & HAJIMEHDIPOOR, H., & JAMILI, S., & RUSTAIYAN, A., & GOHARI, A. (2013). A CYTOTOXIC HYDROPEROXY STEROL FROM THE BROWN ALGA, NIZAMUDDINIA ZANARDINII. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 21(3), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=341001



Vancouver: Copy

HAMZELOO MOGHADAM MARYAM, FIROUZI JAMILEH, SAEIDNIA SOODABEH, HAJIMEHDIPOOR HOMA, JAMILI SHAHLA, RUSTAIYAN ABDOLHOSSEIN, GOHARI AHMAD R.. A CYTOTOXIC HYDROPEROXY STEROL FROM THE BROWN ALGA, NIZAMUDDINIA ZANARDINII. DARU JOURNAL OF PHARMACEUTICAL SCIENCE. 2013 [cited 2021October20];21(3):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=341001



IEEE: Copy

HAMZELOO MOGHADAM, M., FIROUZI, J., SAEIDNIA, S., HAJIMEHDIPOOR, H., JAMILI, S., RUSTAIYAN, A., GOHARI, A., 2013. A CYTOTOXIC HYDROPEROXY STEROL FROM THE BROWN ALGA, NIZAMUDDINIA ZANARDINII. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, [online] 21(3), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=341001.



 
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