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Paper Information

Journal:   IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   JULY 2012 , Volume 14 , Number 2 (SN 62); Page(s) 127 To 134.
 
Paper: 

GLUCOSE INTOLERANCE IN SUBCLINICAL HYPERTHYROID PATIENTS

 
 
Author(s):  MOAZEZI Z., HEDAYATI M., SHIRKHANI Z., AZIZI F.*
 
* ENDOCRINE RESEARCH CENTER, RESEARCH INSTITUTE FOR ENDOCRINE SCIENCES, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, I.R. IRAN
 
Abstract: 

Introduction: In overt hyperthyroidism, although impaired glucose tolerance has long been observed as a frequent complication, the impact of subclinical hyperthyroidism on glucose metabolism is unclear. Therefore, we compared glucose tolerance tests in patients with subclinical hyperthyroidism and a group of healthy controls.
Materials and Methods: Forty- five patients with a drug history of therapy with Levothyroxine and 14 healthy controls were enrolled and T4, T3, T3RU, TSH were measured prior to and TSH again after intravenous injection of 250 mg TRH. Oral glucose tolerance test was performed after 7 to 11 days. The data obtained for patients with subclinical hyperthyroidism and euthyroid healthy controls were compared.
Results: Twenty-five patients and one control had subclinical hyperthyroidism based on basal TSH. Basal glucoseconcentrations were not significantly different between the subclinical hyperthyroidism and euthyroidism group. Plasma glucose levels (milligrams per dl
±SEM) at 90 and 120 minutes after ingestion of glucose were significantly higher (p=0.005 and p=0.06 respectively) in the subclinical hyperthyroid (SHR) patients (162±17, 146±16 respectively) compared to euthyroid (EU) normal subjects (101±7 and 94±5 respectively). SHR patients showed higher postprandial glucose concentrations (area under the curve, AUC90, 120 18072±4779 and 18130±1758 mg/dlmin±SEM respectively) versus EU normal subjects (AUC90, 120 1045±516, 13360±643 mg/dl min±SEM, P=0.026, 0.018 respectively).
Conclusion: Subclinical hyperthyroidism results in glucose intolerance despite normal fasting plasma glucose, findings that recommend oral glucose tolerance tests for SHR patients.

 
Keyword(s): SUBCLINICAL HYPERTHYROIDISM, GLUCOSE INTOLERANCE , HYPERTHYOIDISM, DIABETES MELLITUS
 
References: 
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