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Paper Information

Journal:   JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)   Spring 2005 , Volume 7 , Number 2 (26); Page(s) 24 To 29.
 
Paper: 

ASSESSMENT OF HYDROALCOHOLIC EXTRACT OF THYMUS VULGARIS ON NEUROGENIC AND INFLAMMATORY PAIN IN MICE

 
 
Author(s):  TAHERIAN ABAS ALI*, RASHIDIPOUR A., AREFI M., VAFAEI A.A., EMAMI ABARGHOUEI M., SADEGHI HASAN, JARAHI M., MILADI GORJI H.
 
* RESEARCH CENTER OF PHYSIOLOGY, FACULTY OF MEDICINE, SEMNAN UNIV MEDICAL SCIENCES,SEMNAN, IRAN
 
Abstract: 
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Background and OBJECTIVE: The side effects of antinociception chemical drugs caused notice to medical plants. This study was performed to investigate the effects of hydro alcoholic extract of thymus vulgaris (TV) on neurogenic and inflammatory pain in formalin test in mice.
METHODS: Forty male albino mice (20-30 gr) were used. TV (100, 500 mg/kg) as extract and saline were injected 30 min before formalin test. Indexes for evaluation were duration of licking and foot elevation for assessment of acute pain (5 min) and chronic pain (15-40 min) after injection of formalin 5% (25µl) in paw.
FINDINGS: Results indicated that TV has analgesic effect in both doses (p<0.01), and higher dose (500 mg) was more effective.
CONCLUSION: Findings showed that hydro alcoholic extract of TV can modulate acute and chronic pain. Further research is required to determine the mechanisms by which TV has an inhibitory effect on pain sensation

 
Keyword(s): THYMUS VULGARIS, NEUROGENIC AND INFLAMMATORY PAIN, FORMALIN TEST
 
References: 
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