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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   JULY-SEPTEMBER 2013 , Volume 7 , Number 2; Page(s) 116 To 121.
 
Paper: 

VITAMIN D RECEPTOR TAQI GENE VARIANT IN EXON 9 AND POLYCYSTIC OVARY SYNDROME RISK

 
 
Author(s):  BAGHERI MORTEZA, ABDI RAD ISA*, HOSSEINI JAZANI NIMA*, NANBAKHSH FARIBA
 
* FOOD AND BEVERAGES SAFETY RESEARCH CENTER, URMIA UNIVERSITY OF MEDICAL SCIENCES, URMIA, IRAN
 
Abstract: 

Background: Polycystic ovary syndrome (PCOS) is known as a metabolic disorder. The results of recent studies implied that vitamin D receptor (VDR) genetic variants may impact PCOS and insulin resistance in women with PCOS. The aim of the present study was to determine the VDR TaqI gene variant in exon 9 (T/C) (rs731236) in normal controls and patients with PCOS for the first time in Iranian Azeri women.
Materials and Methods: In this case control study between April 2011 and June 2012, a total of 76 women aged 18-40 years (38 patients with PCOS and 38 healthy women as normal controls) participated. Genotypes of VDR TaqI in exon 9 (T/C) (rs731236) were determined using the PCR-RFLP method.
Results: The frequencies of VDR TaqI T anc C alleles were 0.605 and 0.395 in cases and 0.697 and 0.303 in controls. Also, the genotypic frequencies of VDR TaqI were 16) (42.11), 14 (36.84), and 8 (21.05) in cases, and 17 (44.74), 19 (50), and 2 (5.26) in controls for TT, TC and CC genotypes respectively. There was no difference in genotype and allele frequencies between PCOS and controls (p value>0.05) with the exception of the CC genotype (p value=0.04).
Conclusion: This report, a first of its own kind in Iranian Azeri patients, suggests that the CC genotype of VDR TaqI in exon 9 (rs731236) is associated with PCOS.

 
Keyword(s): VITAMIN D RECEPTOR, POLYCYSTIC OVARY SYNDROME, GENETIC VARIATION
 
 
References: 
 
Citations: 
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APA: Copy

BAGHERI, M., & ABDI RAD, I., & HOSSEINI JAZANI, N., & NANBAKHSH, F. (2013). VITAMIN D RECEPTOR TAQI GENE VARIANT IN EXON 9 AND POLYCYSTIC OVARY SYNDROME RISK. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 7(2), 116-121. https://www.sid.ir/en/journal/ViewPaper.aspx?id=320039



Vancouver: Copy

BAGHERI MORTEZA, ABDI RAD ISA, HOSSEINI JAZANI NIMA, NANBAKHSH FARIBA. VITAMIN D RECEPTOR TAQI GENE VARIANT IN EXON 9 AND POLYCYSTIC OVARY SYNDROME RISK. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY. 2013 [cited 2021October19];7(2):116-121. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=320039



IEEE: Copy

BAGHERI, M., ABDI RAD, I., HOSSEINI JAZANI, N., NANBAKHSH, F., 2013. VITAMIN D RECEPTOR TAQI GENE VARIANT IN EXON 9 AND POLYCYSTIC OVARY SYNDROME RISK. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, [online] 7(2), pp.116-121. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=320039.



 
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