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Paper Information

Journal:   BINA   Spring 2000 , Volume 5 , Number 3; Page(s) 199 To 204.
 
Paper: 

THE INCIDENCE OF ABNORMAL OCULAR FINDINGS IN SICKLE CELL DISEASE

 
 
Author(s):  ATARZADEH A., SHAD DEL M.
 
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Abstract: 

Purpose: To determine the incidence of abnormal ocular findings in patients with sickle cell disease. Material and methods: 30 patients with sickle cell disease were randomly selected. Diagnosis of sickle cell disease was based on complete blood count and morphologic examination of a peripheral blood sample and hemoglobin electrophoresis. Age and sex of the patients were recorded and a complete ocular examination including visual acuity, tonometry and funduscopy was done. The specific type of sickle cell disease any associated diseases and any medication used, were also recorded.
Results: 60 eyes of 30 patients with a mean age of 14 years (5-46 years) were studied. 17 patients were female and 13 were male. 14 patients had sickle thalassemia, 11 patients had sickle cell anemia (SS) and 5 patients had sickle cell trail (AS). 8 patients had comma-shaped conjuctival vessels (1 sickle cell trait and 2 sickle cell anemia). A notable finding was the presence of small iris nodules in 11 patients with sickle thalassemia. Iris atrophy was not seen in any case. Ophthalmoscopy did not reveal any retinal neovascularization, macular hole, retinal detachment or angioid streaks. The only funduscopic findings were the presence of venous tortusity in 2 patients and optic nerve atrophy in 1 patient; all 3 of these patients had sickle cell anemia (SS).
Conclusion: Patients with sickle cell disease, especially sickle cell anemia (SS), should receive regular ophthalmic examinations. Any decrease in visual acuity of these patients mandates the performance of a complete eye examination.

 
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