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Paper Information

Journal:   THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES   Summer 2000 , Volume 11 , Number 2; Page(s) 133 To 141.
 
Paper: 

GASTRIC METAPLASIA AND HELICOBACTER PYLORI IN DUODENAL ULCER AND NON ULCER DYSPEPSIA

 
 
Author(s):  BEHROUZIAN R., GHAVAM F., ANSARI M.H., AGHDAMI N., HESHMAT RAMIN
 
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Abstract: 

Objectives: Duodenal Ulcer (DU) that appears with mucosal defect, is a common disease. About 10 percent of people suffer from DU and its complications during their life long. Recent hypothesis emphasis on Helicobacter pylori as the main pathogen. But some studies indicate that such a role can be a confounder. The main goal of this case-control study is the determination of Gastric metoplasia and Helicobacter pylori infection in DU and comparison with Non Ulcer Dyspepsia (NUD).
Methods: Patients with endoscopically confirmed DU and NUD were undertaken Duodenal biopsy to determine gastric metaplasia and Ureas and ELIAS tests to recognition of Helicobacter pylori infection. A total of 77 patients (37 in group Du & 40 in group NUD) were studied (68.8% male & 31.2% female).
Results: Helicobacter pylori infection and gastric metaplasia rate were 55.8% and 50.6% respectively. There was no difference in two groups H.pylori. On the other hand, gastric metaplasia was significantly higher in NUD group that DU group. H.pylori infection was more frequent among patients with gastric metaplasia.
Conclusion: The results of this study indicate higher gastric metaplasia rate in NUD group. On the other hand, more Helicobacter pylori infection in patients with gastric metaplasia points to relation of this microorganism and gastric metaplasia than Duodenal ulcer. Although some studies confirm such a finding, there is a necessity to perform the vast studies in proof of the subject.

 
Keyword(s): DUODENAL ULCER, HELICOBACTER PYLORI, GASTRIC METAPLASIA
 
References: 
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