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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   Summer 2004 , Volume 3 , Number 3; Page(s) 181 To 185.
 
Paper: 

HYPNOTIC EFFECT OF ROSA DAMASCENA IN MICE

 
 
Author(s):  RAKHSHANDAH H.*, HOSSEINI M., DOULATI K.
 
* DEPARTMENT OF PHARMACOLOGY, GHAEM MEDICAL CENTER, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Rosa damascena (Rosaceae) has been found to act on central nervous system including the brain. Several studies confirm that Rosa damascena inhibits the reactivity of the hypothalamus and pituitary systems in rat and can suppress the reactivity of central nervous system. In traditional medicine the hypnotic effect of rose is also suggested. In the present study hypnotic effect of ethanolic, aqueousand chloroformic extracts of Rosa damascena was investigated in mice. Hypnotic method was based on potentiation of pentobarbital induced sleeping time by extracts. Three doses of extracts (100, 500 and 1000 mg/kg) were injected intraperitoneally in comparisonwith diazepam (3 mg/kg) as the positivecontroland salineas the negative control. Thirty min after injection of extracts, pentobarbital (30 mg/kg) was injecteci and any increase in the sleeping time due to the extracts was recorded. Results showed that the ethaholic and aqueous extracts in doses of 500 and 1000 mg/kg significantly increased the pentobarbital induced sleeping time (P<0.001, compared to the negative control), which was comparableto diazepam. The chloroformic extract showed no hypnotic effect.

 
Keyword(s): MICE, ROSA DAMASCENA, HYPNOTIC EFFECT, PENTOBARBITAL
 
 
References: 
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Citations: 
 
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APA: Copy

RAKHSHANDAH, H., & HOSSEINI, M., & DOULATI, K. (2004). HYPNOTIC EFFECT OF ROSA DAMASCENA IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 3(3), 181-185. https://www.sid.ir/en/journal/ViewPaper.aspx?id=30108



Vancouver: Copy

RAKHSHANDAH H., HOSSEINI M., DOULATI K.. HYPNOTIC EFFECT OF ROSA DAMASCENA IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR). 2004 [cited 2021June21];3(3):181-185. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=30108



IEEE: Copy

RAKHSHANDAH, H., HOSSEINI, M., DOULATI, K., 2004. HYPNOTIC EFFECT OF ROSA DAMASCENA IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), [online] 3(3), pp.181-185. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=30108.



 
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