Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   ADVANCES IN COGNITIVE SCIENCE   Fall 2002 , Volume 4 , Number 3; Page(s) 1 To 11.
 
Paper: 

THE EFFECTS OF MORPHINE SENSITIZATION ON MORPHINE-STATE-DEPENDENT LEARNING

 
 
Author(s):  ZARINDAST M.R., REZAYOF A.
 
* 
 
Abstract: 

In the present study, the effects of morphine sensitization on morphine-induced impairment of memory formation and the state-dependent retrieval of a passive avoidance task learned under morphine influence have been investigated in mice. Pre-training administration of morphine (0.5, 2.5 and 5mg/kg) dose dependently suppressed the learning of one-trial passive avoidance task. Pre-test administration of morphine (0.5, 2.5 and 5 mg/kg) induced state-dependent retrieval of the memory acquired under pretrainign morphine influence. The inhibitory effect of morphine (5 mg/kg) on memory formation was significantly antagonized by pretreatment administation of naloxone (0.025, 0.5 and 1 mg/kg) before .the pre-training morphine. The pre-test administration of naloxone dose dependently inhibited the restoration induced by morphine (5 mg/kg). Amnesia induced by pre-training morphine significantly was inhibited in morphine-sensitized mice, which had previously received once daily injections of morphine (20 and 30 mg/kg, s.c.) for 3 days. Morphine sensitization did not affect on morphine state-dependent memory of passive avoidance. The inhibition of morphine-induced amnesia in morphine-sensitized mice was suppressed by one daily injections of naloxone (0.5, 1 and 2 mg/kg) 30 min prior to s.c. injections of morphine (20 mg/kg/day × 3 days). These results suggest that morphine sensitization affect the impairment of memory formation, but not the facilitation of retrieval induced by morphine.

 
Keyword(s): 
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

ZARINDAST, M., & REZAYOF, A. (2002). THE EFFECTS OF MORPHINE SENSITIZATION ON MORPHINE-STATE-DEPENDENT LEARNING. ADVANCES IN COGNITIVE SCIENCE, 4(3), 1-11. https://www.sid.ir/en/journal/ViewPaper.aspx?id=29804



Vancouver: Copy

ZARINDAST M.R., REZAYOF A.. THE EFFECTS OF MORPHINE SENSITIZATION ON MORPHINE-STATE-DEPENDENT LEARNING. ADVANCES IN COGNITIVE SCIENCE. 2002 [cited 2021October20];4(3):1-11. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=29804



IEEE: Copy

ZARINDAST, M., REZAYOF, A., 2002. THE EFFECTS OF MORPHINE SENSITIZATION ON MORPHINE-STATE-DEPENDENT LEARNING. ADVANCES IN COGNITIVE SCIENCE, [online] 4(3), pp.1-11. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=29804.



 
 
Persian Abstract Yearly Visit 50
 
 
Latest on Blog
Enter SID Blog