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Paper Information

Journal:   VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)   SPRING 2012 , Volume 6 , Number 1 (21); Page(s) 1493 To 1503.
 
Paper: 

HISTOPATHOLOGICAL STUDY ON THE EFFECTS OF TURMERIC (CURCUMA LONGA LINN.) POWDWER ON RENAL ISCHEMIA-REPERFUSION INJURYIN RATS

 
 
Author(s):  MOHAJERI D.*, MOUSAVI GH., MANSOURI M.B.
 
* DEPARTMENT OF PATOBIOLOGY, FACULTY OF VETERINARY MEDICINE, TABRIZ BRANCH, ISLAMIC AZAD UNIVERSITY, TABRIZ, IRAN
 
Abstract: 

Renal ischemia/reperfusion (I/R) injury is a major cause of acute renal failure (ARF), which is faced in many clinical situations. This study was designed to investigate the effect of pre-treatment with turmeric (Curcuma longa linn) powder on kidney histopathology and function markers in renal ischemia / reperfusion (IR) induced injury in the rats. A total of 80 male Wistar rats were randomly divided into 4 groups: sham, IR model and two I/R+TREE (2%and4%) - treated groups (n=20 per group). I/R groups’ kidneys were subjected to 60 min of global ischemia at 37oc followed by 30min of reperfusion. After 24h of reperfusion period, the rats were sacrificed. Kidney function tests and histopathological examination were also performed. Results were compared with a group of rats with sham operation. High serum creatinine, blood urea nitrogen and uric acid were observed in I/R rats compared to the sham rats. Pre-treatment of turmeric powder for 30 days prior to IR operation improved renal function reduced IR induced renal inflammatory and oxidative injury. The results of this study showed that turmeric powder significantly prevented renal I/R-induced functional and histological injuries.

 
Keyword(s): CURCUMA LONGA LINN, ISCHEMIA-REPERFUSION, KIDNEY, RAT
 
 
References: 
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Cite:
APA: Copy

MOHAJERI, D., & MOUSAVI, G., & MANSOURI, M. (2012). HISTOPATHOLOGICAL STUDY ON THE EFFECTS OF TURMERIC (CURCUMA LONGA LINN.) POWDWER ON RENAL ISCHEMIA-REPERFUSION INJURYIN RATS. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 6(1 (21)), 1493-1503. https://www.sid.ir/en/journal/ViewPaper.aspx?id=295655



Vancouver: Copy

MOHAJERI D., MOUSAVI GH., MANSOURI M.B.. HISTOPATHOLOGICAL STUDY ON THE EFFECTS OF TURMERIC (CURCUMA LONGA LINN.) POWDWER ON RENAL ISCHEMIA-REPERFUSION INJURYIN RATS. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ). 2012 [cited 2021April11];6(1 (21)):1493-1503. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=295655



IEEE: Copy

MOHAJERI, D., MOUSAVI, G., MANSOURI, M., 2012. HISTOPATHOLOGICAL STUDY ON THE EFFECTS OF TURMERIC (CURCUMA LONGA LINN.) POWDWER ON RENAL ISCHEMIA-REPERFUSION INJURYIN RATS. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), [online] 6(1 (21)), pp.1493-1503. Available at: <https://www.sid.ir/en/journal/ViewPaper.aspx?id=295655>.



 
 
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