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Paper Information

Journal:   PHYSIOLOGY AND PHARMACOLOGY   FALL 2012 , Volume 16 , Number 3; Page(s) 222 To 230.
 
Paper: 

EFFECT OF MINOCYCLINE ON AMYGDALA KINDLING ACQUISITION IN RATS

 
 
Author(s):  BEHESHTI NASR SEYED MEHDI, MOGHIMI ALI, MOHAMMAD ZADEH M.*
 
* CELLULAR AND MOLECULAR RESEARCH CENTER, SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, SABZEVAR, IRAN
 
Abstract: 

Introduction: Minocycline is a derivative of tetracycline that has anti-inflammatory, antiappoptic, antioxidant and neuroprotective effects. Since there is a relationship between cell death and seizure, the aim of this study was to examine the role of minocycline in development of amygdala kindling in Wistar rats.
Methods: In this study, 21 rats were divided into three groups. After stereotaxic surgery and 1 week recovery period, rats received kindling stimulations (twice daily at 6 hour intervals). Group 1 (n=7) received daily kindling stimulations.
Groups 2 (n=7) and 3 (n=7) received saline (1 ml/kg) and minocycline (25 mg/kg), respectively, 60 min before kindling stimulation. Cumulative After discharge Duration (ADD), Cumulative Seizure duration (SD) and Seizure Stage (SS) were recorded and compared to the control group.
Results: In group 3, intraperitoneal administration of minocycline for 10 days significantly reduced cumulative ADD (control group: 907.2±64.5, minocycline group: 717.8±67.9) [F(18, 216)=3.5, p<0.001], and cumulative SD (control group: 999.4±79.8, minocycline group: 776.1±77) [F(19, 228)=3.8, p<0.001] compared to control group (group 2). It also significantly increased the mean number of stimulations to achieve the seizure stage 3 (control group: 7.2±0.6, minocycline group: 11±1) (P<0.05), and 5 (control group: 10.7±0.1, minocycline group: 18.7±0.3) (P<0.001).
Conclusion: According to the obtained results, application of minocycline increases the time required for amygdala kindling and may have anticonvulsant effects.

 
Keyword(s): SEIZURE, KINDLING, MINOCYCLINE, RAT
 
 
References: 
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Citations: 
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APA: Copy

BEHESHTI NASR, S., & MOGHIMI, A., & MOHAMMAD ZADEH, M. (2012). EFFECT OF MINOCYCLINE ON AMYGDALA KINDLING ACQUISITION IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 16(3), 222-230. https://www.sid.ir/en/journal/ViewPaper.aspx?id=285892



Vancouver: Copy

BEHESHTI NASR SEYED MEHDI, MOGHIMI ALI, MOHAMMAD ZADEH M.. EFFECT OF MINOCYCLINE ON AMYGDALA KINDLING ACQUISITION IN RATS. PHYSIOLOGY AND PHARMACOLOGY. 2012 [cited 2021October25];16(3):222-230. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=285892



IEEE: Copy

BEHESHTI NASR, S., MOGHIMI, A., MOHAMMAD ZADEH, M., 2012. EFFECT OF MINOCYCLINE ON AMYGDALA KINDLING ACQUISITION IN RATS. PHYSIOLOGY AND PHARMACOLOGY, [online] 16(3), pp.222-230. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=285892.



 
 
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