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Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   WINTER 2002 , Volume 6 , Number SPECIAL ISSUE 6 (26); Page(s) 503 To 506.
 
Paper: 

EFFECTS OF RADIOTHERAPY AND CHEMOTHERAPY ON ELECTROCARDIOGRAPHY OF PATIENTS WITH LEFT BREAST CANCER

 
 
Author(s):  MORTAZAVI H., YAHYAZADEH H.*, MIRI R.
 
* Department of Radiotherapy-Oncology Shaheed Beheshti University of Medical Sciences
 
Abstract: 

Background: With respect to the known cardiac side effects of radiation and higher risk of these effects on patients with left breast cancer under radiation therapy following mastectomy, the present study was carried out in Radiotherapy-Oncology Department in Imam Hossein hospital in 2000 to determine the effects of radiotherapy on electrocardiography of the aforementioned patients.
Materials and methods: 73 females referring for radiotherapy have enrolled in this clinical trial. They had undergone a modified radical mastectomy operation and received adequate chemotherapy protocol. Factors included in our study were menstruation state, adriamycin chemotherapy protocol, and number of radiation fields.
Results: The mean age of the candidates was 47 years. Short-term and long-term ECG changes in T wave and ST segment were reported 27% and 70%, respectively. In case of adriamycin administration, ECG changes occur sooner with greater severity. With increasing the number of radiotherapy fields, the risk of ECG changes increased, however, the time of its development decreased. Postmenopausal females had experienced further ECG changes.
Conclusion: Results have revealed short- and long-term ECG changes following the radiotherapy and chemotherapy. Thus, cardiac studies should be more seriously taken into account in the affected females.

 
Keyword(s): RADIOFREQUENCY, ADRIAMYCIN, CARDIAC COMPLICATIONS, ECG
 
References: 
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