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Paper Information

Journal:   JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES   SPRING 2011 , Volume 10 , Number 1 (38); Page(s) 46 To 61.
 
Paper: 

NEUROPROTECTION EFFECT OF FEMALE SEX STEROIDS AFTER TRAUMATIC BRAIN INJURY IN RATS: THE ROLE OF INFLAMMATORY CYTOKINES

 
 
Author(s):  SARKAKI A.R.*, KHAKSARI HADDAD M., SOLTANI Z., KESHAVARZI Z., SHAHROKHI N., ASADI KARAM G.R., ABBASSI R.
 
* DEPT. OF PHYSIOLOGY, PHYSIOLOGY RESEARCH CENTER, JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHWAZ, IRAN
 
Abstract: 

Background and Objectives: Previous studies have demonstrated estrogen and progesterone decrease brain edema induced by TBI. The aim of the present study was to determine the effect of female sex steroids on cytokines, and proinflammatory evaluation of the effects of cerebral edema of these hormones whether ovarian hormones decrease brain edema by change in concentrations of proinflammatory cytokines.
Materials and Methods: In this experimental study, 98 ovariectomized female rats (except groups 1 and 2) were divided into groups of control, sham, vehicle, low does of estrogen (E1), high dose of estrogen (E2), low dose of progesterone (P1) and high dose of progesterone (P2). Vehicle and sexual steroid hormones were injected intraperitoneally at 0.5 h after Moderate and diffuse TBI induced by Marmarou method. Brain level of cytokines and ovarian hormones were measured 6 h after TBI by ELISA method.
Results: Both E2 and P1 caused significant increase of 52.8% and 79.2% in brain level of IL-1
b. P2 significantly decreased the levels of IL-6 and TNF-a by 45.9% and 72% respectively. TGF-b level seem to be increased by E1 up to 3.37 times significantly. Level of b-Estradiol increased 4.58 times in E2 group and progesterone increased 1.56 times in P2 group significantly.
Conclusion: This results suggested that ovarian hormones increased brain IL-1
b and TGF-b and decreased IL-6 and TNF-a, this may be one mechanism by which hormones reduce cerebral edema.

 
Keyword(s): TBI, OVARIAN HORMONES, IL-1β, IL-6, TNF-α, TGF-β
 
 
References: 
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Citations: 
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APA: Copy

SARKAKI, A., & KHAKSARI HADDAD, M., & SOLTANI, Z., & KESHAVARZI, Z., & SHAHROKHI, N., & ASADI KARAM, G., & ABBASSI, R. (2011). NEUROPROTECTION EFFECT OF FEMALE SEX STEROIDS AFTER TRAUMATIC BRAIN INJURY IN RATS: THE ROLE OF INFLAMMATORY CYTOKINES. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 10(1 (38)), 46-61. https://www.sid.ir/en/journal/ViewPaper.aspx?id=279208



Vancouver: Copy

SARKAKI A.R., KHAKSARI HADDAD M., SOLTANI Z., KESHAVARZI Z., SHAHROKHI N., ASADI KARAM G.R., ABBASSI R.. NEUROPROTECTION EFFECT OF FEMALE SEX STEROIDS AFTER TRAUMATIC BRAIN INJURY IN RATS: THE ROLE OF INFLAMMATORY CYTOKINES. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES. 2011 [cited 2021October23];10(1 (38)):46-61. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=279208



IEEE: Copy

SARKAKI, A., KHAKSARI HADDAD, M., SOLTANI, Z., KESHAVARZI, Z., SHAHROKHI, N., ASADI KARAM, G., ABBASSI, R., 2011. NEUROPROTECTION EFFECT OF FEMALE SEX STEROIDS AFTER TRAUMATIC BRAIN INJURY IN RATS: THE ROLE OF INFLAMMATORY CYTOKINES. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, [online] 10(1 (38)), pp.46-61. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=279208.



 
 
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