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Paper Information

Journal:   IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   MAY 2012 , Volume 14 , Number 1 (SN 61); Page(s) 68 To 74.
 
Paper: 

THE EFFECT OF 4 WEEKS RESISTANCE TRAINING ON SERUM VASPIN, IL-6, CRP AND TNF-Α CONCENTRATIONS IN DIABETIC RATS

 
 
Author(s):  SAFARZADEH A., GHARAKHANLOU R.*, HEDAYATI M., TALEBI GARAKANI E.
 
* DEPARTMENT OF PHYSICAL EDUCATION AND SPORT SCIENCE, FACULTY OF HUMANITY, TARBIAT MODARES UNIVERSITY, TEHRAN
 
Abstract: 

Introduction: Vaspin is a novel adipokine that potentially improves insulin sensitivity. However, there is limited information available regarding the effect of exercise training on serum vaspin concentrations. The purpose of this study was to investigate the effect of resistance training on serum vaspin levels and some inflammatory markers in diabetic status.
Materials and Methods: Thirty six male Wister rats (288±22 g) were randomly divided into four groups: Non-diabetic control, non-diabetic trained, diabetic control and diabetic trained. The exercise groups were subjected to a resistance training program with the use of a ladder (3 days/wk, for 4 wk). Body weight, serum vaspin, C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor (TNF)-
a and fasting glucose were measured.
Results: Four weeks resistance exercise training in nondiabetic rats decreased serum vaspin levels significantly, while in the trained diabetic group, serum vaspin levels increased significantly when compared with the diabetic sedentary group. The resistance training programme did not however change TNF-
a, IL-6 and glucose concentrations. A decrease in CRP was observed in both the resistance trained groups when compared with their control groups.
Conclusion: We found that resistance training exercise programmes affected the serum vaspin response of diabetic and non-diabetic groups of rats differently. However further research is warranted in order to unravel the molecular mechanism for the range of responses and the role of serum vaspin. Decreased levels of CRP may also be indicative of the possible effect of resistance training to modulate pro-inflammatory parameters linked to diabetes.

 
Keyword(s): DIABETES MELLITUS, RESISTANCE TRAINING, SERPIN A12, SYSTEMIC INFLAMMATION
 
 
References: 
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Citations: 
 
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APA: Copy

SAFARZADEH, A., & GHARAKHANLOU, R., & HEDAYATI, M., & TALEBI GARAKANI, E. (2012). THE EFFECT OF 4 WEEKS RESISTANCE TRAINING ON SERUM VASPIN, IL-6, CRP AND TNF-Α CONCENTRATIONS IN DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 14(1 (SN 61)), 68-74. https://www.sid.ir/en/journal/ViewPaper.aspx?id=275754



Vancouver: Copy

SAFARZADEH A., GHARAKHANLOU R., HEDAYATI M., TALEBI GARAKANI E.. THE EFFECT OF 4 WEEKS RESISTANCE TRAINING ON SERUM VASPIN, IL-6, CRP AND TNF-Α CONCENTRATIONS IN DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM). 2012 [cited 2021October18];14(1 (SN 61)):68-74. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=275754



IEEE: Copy

SAFARZADEH, A., GHARAKHANLOU, R., HEDAYATI, M., TALEBI GARAKANI, E., 2012. THE EFFECT OF 4 WEEKS RESISTANCE TRAINING ON SERUM VASPIN, IL-6, CRP AND TNF-Α CONCENTRATIONS IN DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), [online] 14(1 (SN 61)), pp.68-74. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=275754.



 
 
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