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Paper Information

Journal:   JOURNAL OF TROPICAL MEDICINE AND HYGIENE   1993 , Volume 96 , Number 4; Page(s) 237 To 240.
 
Paper: 

ASSESSMENT OF THE RESPONSE IN-VIVO AND IN-VITRO OF PLASMODIUM-FALCIPARUM TO SULFADOXINE PYRIMETHAMINE IN THE MALARIOUS AREAS OF IRAN

 
 
Author(s):  EDRISIAN GH.H.*, AFSHAR A., SAYADZADEH A., MOHSSENI G., SATVAT M.T.
 
* TEHRAN UNIV MED SCI, SCH PUBL HLTH, TEHRAN, IRAN
 
Abstract: 
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Studies of drug resistance of Plasmodium falciparum cases from SE Iran were carried out in vivo and in vitro during 1990-91. In a study of 26 chloroquine-resistant infections, using amodiaquine (25 mg kg-1 over 3 days), followed by two-thirds of the standard dose of sulphadoxine-pyrimethamine, six cases were resistant at the RI(3) and RII(3) levels. An additional study testing the standard dose of sulphadoxine-pyrimethamine in 43 chloroquine-resistant cases revealed five (11.6%) resistant at the RI(2) and RII(3) levels. Six of the above resistant infections were contracted in Hormozgan, three in Sistan-Baluchestan, one in Kerman provinces of Iran and one in Pakistan.
In five of 22 successful in-vitro tests, carried out on different isolates, the parasites grew to schizonts (greater-than-or-equal-to 8 nuclei) in the wells containing 1000 pmol sulphadoxine and 12.5 pmol pyrimethamine, indicative of resistance.
 
Keyword(s): PLASMODIUM-FALCIPARUM, SULFADOXINE PYRIMETHAMINE, RESISTANCE, IRAN
 
 
References: 
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Citations: 
 
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APA: Copy

EDRISIAN, G., & AFSHAR, A., & SAYADZADEH, A., & MOHSSENI, G., & SATVAT, M. (1993). ASSESSMENT OF THE RESPONSE IN-VIVO AND IN-VITRO OF PLASMODIUM-FALCIPARUM TO SULFADOXINE PYRIMETHAMINE IN THE MALARIOUS AREAS OF IRAN . JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 96(4), 237-240. https://www.sid.ir/en/journal/ViewPaper.aspx?id=26620



Vancouver: Copy

EDRISIAN GH.H., AFSHAR A., SAYADZADEH A., MOHSSENI G., SATVAT M.T.. ASSESSMENT OF THE RESPONSE IN-VIVO AND IN-VITRO OF PLASMODIUM-FALCIPARUM TO SULFADOXINE PYRIMETHAMINE IN THE MALARIOUS AREAS OF IRAN . JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 1993 [cited 2021November29];96(4):237-240. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=26620



IEEE: Copy

EDRISIAN, G., AFSHAR, A., SAYADZADEH, A., MOHSSENI, G., SATVAT, M., 1993. ASSESSMENT OF THE RESPONSE IN-VIVO AND IN-VITRO OF PLASMODIUM-FALCIPARUM TO SULFADOXINE PYRIMETHAMINE IN THE MALARIOUS AREAS OF IRAN . JOURNAL OF TROPICAL MEDICINE AND HYGIENE, [online] 96(4), pp.237-240. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=26620.



 
 
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