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Paper Information

Journal:   JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES   FALL 2011 , Volume 18 , Number 3 (48); Page(s) 168 To 173.
 
Paper: 

EFFECTS OF MORPHINE ON PROLIFERATION OF A549 LUNG CANCER

 
 
Author(s):  LATIFPOUR M.*, MOHAMMADIPOUR A.
 
* DEPARTMENT OF ANATOMY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background and Aim: Morphine is frequently used for patients suffering cancer in their end stages to relive pain. However, there are conflicting reports suggesting morphine to promote tumor growth and reduce survival rate in cancerous animal models or induce necrosis and apoptosis in the tumor cells. In the present study, we studied the effect of morphine on proliferation of human lung adenocarcinoma epithelial cell line (A549).
Materials and Methods: In this experimental study, after culturing A549 line cells, a suspension of 105 cell/ml was obtained. Then a concentration of 104 cell/100µl was added to each 96 wells of the plates. The wells were then categorized into three groups including control (containing no morphine), morphine 10 (containing10µm morphine) and morphine 30 (containing 30µm morphine). After 24h of incubation, the proliferations of A549 cells were examined using WST-1 cell counting Kit and Eliza method.
Results: Morphine induced proliferation in lung tumor cells; there was a significant association between increase in dose of morphine and rate of cell proliferation. Mean absorption dose in the group recieving 30µM of morphine (1.82±0.18) was significantly different from those recieving 10µM (1.52±0.08) or no morphine (1.44±0.09) (P<0.05(.
Conclusion: Rate of cell proliferation is increased with increasing doses of morphine in lung cancer. We propose use of morphine with more caution in lung cancer patients.

 
Keyword(s): MORPHINE, PROLIFERATION, A549 CELL LINE
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

LATIFPOUR, M., & MOHAMMADIPOUR, A. (2011). EFFECTS OF MORPHINE ON PROLIFERATION OF A549 LUNG CANCER. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 18(3 (48)), 168-173. https://www.sid.ir/en/journal/ViewPaper.aspx?id=265985



Vancouver: Copy

LATIFPOUR M., MOHAMMADIPOUR A.. EFFECTS OF MORPHINE ON PROLIFERATION OF A549 LUNG CANCER. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES. 2011 [cited 2021October22];18(3 (48)):168-173. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=265985



IEEE: Copy

LATIFPOUR, M., MOHAMMADIPOUR, A., 2011. EFFECTS OF MORPHINE ON PROLIFERATION OF A549 LUNG CANCER. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, [online] 18(3 (48)), pp.168-173. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=265985.



 
 
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