Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JOURNAL OF SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH   FALL 2011 , Volume 9 , Number 3; Page(s) 73 To 81.
 
Paper: 

THE EFFECTS OF DIETARY OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY BIOMARKERS IN TYPE-2 DIABETIC PATIENTS

 
 
Author(s):  MALEKSHAHI MOGHADAM A., SAEDISOMEOLIA A.*, DJALALI M., SOJOUDI F.
 
* DEPARTMENT OF NUTRITION AND BIOCHEMISTRY, SCHOOL OF PUBLIC HEALTH, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background and Aim: Omega-3 fatty acids can reduce inflammation in diabetic patients via special mechanisms. The objective the current study was to investigate the effects dietary omega-3 fatty acid supplementation on the serum levels of C-reactive protein (CRP), interleukin-2 (IL-2), and tumor necrosis factor-alpha (TNF-a) in type 2 diabetes patients.
Materials and Methods: This randomized double-blind placebo-controlled clinical trial was conducted on 57 subjects with type-2 diabetes. The participants were randomly assigned to one of 2 groups receiving either an omega-3 fatty acid supplement (containing 1584 mg eicosapentaenoic acid, 828 mg docosahexaenoic acid, and 338 mg other omega-3 fatty acids) or a placebo tablet (containing 2100 mg sunflower oil) for a period of 8 weeks.
Results: The serum TNF-
a and IL-2 concentrations decreased significantly in the omega-3 fatty acid group in comparison with the placebo group (in both cases, p<0.01). The intervention did not bring about any statistically significant changes in the serum CRP concentrations.
Conclusion: Considering the beneficial effects of omega-3 dietary fatty acid supplements on the 2 inflammatory biomarkers, namely TNF-
a and IL-2, type-2 diabetes patients are recommended to consume such supplements or foodstuffs rich in omega-3 fatty acids, e.g., fish.

 
Keyword(s): OMEGA-3 FATTY ACID, TYPE-2 DIABETES, CRP, TNF-α, IL-2
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 71
 
Latest on Blog
Enter SID Blog