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Paper Information

Journal:   JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES   Spring 2004 , Volume 3 , Number 2; Page(s) 113 To 118.
 
Paper: 

COMPARISON OF THE RESULTS OF TWO THERAPEUTIC METHODS: IMIPRAMINE WITH COMBINATION OF IMIPRAMINE AND OXYBUTYNIN IN UNCOMPLICATED NOCTURNAL ENURESIS IN 6-12 YEAR OLD CHILDREN

 
 
Author(s):  JAMALI M.*, RAFIEI GH.
 
* Dept. of Urology, Moradi Hospital, University of Medical Sciences, Rafsanjan, Iran
 
Abstract: 
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Background: Imipramine is one of the common drugs therapies in enuretic children which is effective 50-60% on average. The main purpose of this research was to investigate the therapeutic effect of the combination of imipramine and oxybutynin compared to imipramine alone in uncomplicated nocturnal enuretic children.
Materials and Methods: This clinical trial study was carried out on 80 primary school children (6-12 years old) with uncomplicated enuresis that were selected among 2500 school children with screening by questionnaire. The children were randomly divided into two groups (40 in each group). One group was treated with Imipramine in combination with Oxybutynin and the other group was treated with Imipramine and placebo for a period of 3 months. After the treatment period, the treated and untreated children were determined.
Results: The frequency of cured with Imipramine and Oxybutynin therapy was 95%, and with Imipramine and placebo was 60%; therefore there was a significant difference between the two therapeutic methods, clinically and statistically (P=0.00017).
Conclusion: The Result of this study showed that Imipramine and Oxybutynin treatment was more effective than Imipramine alone, although we recommend further studies to determine the rate of relapses and side effects of the above methods.

 
Keyword(s): ENURESIS, IMIPRAMINE, OXYBUTYNIN
 
References: 
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