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Paper Information

Journal:   JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES   WINTER 2005 , Volume 4 , Number 1 (13); Page(s) 9 To 16.
 
Paper: 

INCIDENCE OF THROMBOCYTOPENIA INDUCED BY TWO METHODS OF INTRAVENOUS HEPARIN INJECTION IN PATIENTS WITH ACUTE CORONARY SYNDROME

 
 
Author(s):  NOUGH H.*, KHODADADIZADEH A., AREFI M., ESMAIELI NADIMI A.
 
* University of Medical Sciences, Rafsanjan, Iran
 
Abstract: 
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Background: Intravenous heparin is an effective treatment in patients with acute coronary syndrome, and administered either by 6 hours bolus intravenous injection or continuous in fusion. Thrombocytopenia induced by heparin injection have been reported 0-30%, that is variable by different methods of heparin administration. This study was carried out to determine the incidence of thrombocytopenia in both methods of intravenous heparin administration in patients referred to CCU of Aliebn Abitaleb Hospital, Rafsanjan.
Materials and Methods: This clinical trial was carried out in 64 patient (35male and 29 female) with mean age of 52±6 years who admitted in CCU with acute coronary syndrome.
32 patients received continuous infusion (group A) and 32 patients received intermittent intravenous bolus injection of heparin every six hours (group B). Because of hospitalization duration of shorter than 24 hours, 4 patients (2 males and 2 females) from group B and 1 (male) from group A excluded from the study. Dosage of heparin adjusted based on body weight and Aptt measurement of 1.5-2 times of control levels. CBC and platelet count was done on the day of admission, 3 and 7 days after heparin administration.
Results: There were not significant differences between two groups for age, sex and total amounts of prescribed heparin. There were 4 (14.8%) cases with thrombocytopenia in-group B, and one cases (3.1%) in group A, this difference was significant statistically (p<0.05). There was no significant difference in platelet count in group A (210000±20000/mm3) compare to group B (208000±18000/mm3).
Conclusion: Thrombocytopenia induced by heparin, was significantly lower in continuous infusion of heparin compare to intermittent intravenous bolus injection. Therefore continuous infusion of heparin is recommended for patients with acute coronary syndrome who needs heparin therapy.

 
Keyword(s): THROMBOCYTOPENIA, ACUTE CORONARY SYNDROME, INTRAVENOUS INFUSION OF HEPARIN, HEPARIN INTRAVENOUS BLOUS INJECTION
 
 
References: 
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Citations: 
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APA: Copy

NOUGH, H., & KHODADADIZADEH, A., & AREFI, M., & ESMAIELI NADIMI, A. (2005). INCIDENCE OF THROMBOCYTOPENIA INDUCED BY TWO METHODS OF INTRAVENOUS HEPARIN INJECTION IN PATIENTS WITH ACUTE CORONARY SYNDROME. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 4(1 (13)), 9-16. https://www.sid.ir/en/journal/ViewPaper.aspx?id=24802



Vancouver: Copy

NOUGH H., KHODADADIZADEH A., AREFI M., ESMAIELI NADIMI A.. INCIDENCE OF THROMBOCYTOPENIA INDUCED BY TWO METHODS OF INTRAVENOUS HEPARIN INJECTION IN PATIENTS WITH ACUTE CORONARY SYNDROME. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES. 2005 [cited 2021November28];4(1 (13)):9-16. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=24802



IEEE: Copy

NOUGH, H., KHODADADIZADEH, A., AREFI, M., ESMAIELI NADIMI, A., 2005. INCIDENCE OF THROMBOCYTOPENIA INDUCED BY TWO METHODS OF INTRAVENOUS HEPARIN INJECTION IN PATIENTS WITH ACUTE CORONARY SYNDROME. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, [online] 4(1 (13)), pp.9-16. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=24802.



 
 
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