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Paper Information

Journal:   IRANIAN BIOMEDICAL JOURNAL   JANUARY-APRIL 2010 , Volume 14 , Number 1-2; Page(s) 33 To 39.
 
Paper: 

CHRONIC ORAL PELARGONIDIN ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS

 
 
Author(s):  MIRSHEKAR MOHAMMADALI, ROGHANI MEHRDAD*, KHALILI MOHSEN, BALUCHNEJADMOJARAD TOURANDOKHT, ARAB MOAZZEN SAIEDEH
 
* DEPT. OF PHYSIOLOGY, SCHOOL OF MEDICINE, SHAHED UNIVERSITY AND MEDICINAL PLANT RESEARCH CENTER, TEHRAN
 
Abstract: 
Background: Diabetes mellitus in some clinical cases is accompanied with hyperalgesia. In this study, we evaluated the possible beneficial effect of chronic pelargonidin (PG) treatment on hyperalgesia in streptozotocin (STZ) -diabetic neuropathic rat.
Methods: Male Wistar rats (n=56) were divided into seven groups, i.e. control, diabetic, PG-treated control, PG (single- and multiple-dose) -treated diabetic, and sodium salicylate-treated control and diabetics. For induction of diabetes, STZ was injected i.p. at a single dose of 60 mg/kg. PG was orally administered at a dose of 10 mg/kg once and/or on alternate days for 8 weeks; 1 week after diabetes induction. After two months, hyperalgesia was assessed using standard formalin and hot tail immersion tests. Meanwhile, markers of oxidative stress in brain were measured. One-way analysis of variance was used for statistical analysis of the data.
Results: Diabetic rats showed a marked chemical and thermal hyperalgesia, indicating that development of diabetic neuropathy and PG treatment (especially multiple-doses) significantly ameliorated the alteration in hyperalgesia (P<0.05-0.01) in diabetic rats as compared to untreated diabetics. PG (multiple doses) also significantly decreased diabetes-induced thiobarbituric acid reactive substances formation and non-significantly reversed elevation of nitrite level and reduction of antioxidant defensive enzyme superoxide dismutase.
Conclusion: These results clearly suggest that PG prevents diabetic neuropathic hyperalgesia through attenuation of oxidative stress.
 
Keyword(s): PELARGONIDIN (PG), STREPTOZOTOCIN (STZ), OXIDATIVE STRESS
 
 
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APA: Copy

MIRSHEKAR, M., & ROGHANI, M., & KHALILI, M., & BALUCHNEJADMOJARAD, T., & ARAB MOAZZEN, S. (2010). CHRONIC ORAL PELARGONIDIN ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS. IRANIAN BIOMEDICAL JOURNAL, 14(1-2), 33-39. https://www.sid.ir/en/journal/ViewPaper.aspx?id=243571



Vancouver: Copy

MIRSHEKAR MOHAMMADALI, ROGHANI MEHRDAD, KHALILI MOHSEN, BALUCHNEJADMOJARAD TOURANDOKHT, ARAB MOAZZEN SAIEDEH. CHRONIC ORAL PELARGONIDIN ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS. IRANIAN BIOMEDICAL JOURNAL. 2010 [cited 2021October22];14(1-2):33-39. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=243571



IEEE: Copy

MIRSHEKAR, M., ROGHANI, M., KHALILI, M., BALUCHNEJADMOJARAD, T., ARAB MOAZZEN, S., 2010. CHRONIC ORAL PELARGONIDIN ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS. IRANIAN BIOMEDICAL JOURNAL, [online] 14(1-2), pp.33-39. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=243571.



 
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