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Paper Information

Journal:   IRANIAN BIOMEDICAL JOURNAL   JANUARY-APRIL 2010 , Volume 14 , Number 1-2; Page(s) 33 To 39.
 
Paper: 

CHRONIC ORAL PELARGONIDIN ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS

 
 
Author(s):  MIRSHEKAR MOHAMMADALI, ROGHANI MEHRDAD*, KHALILI MOHSEN, BALUCHNEJADMOJARAD TOURANDOKHT, ARAB MOAZZEN SAIEDEH
 
* DEPT. OF PHYSIOLOGY, SCHOOL OF MEDICINE, SHAHED UNIVERSITY AND MEDICINAL PLANT RESEARCH CENTER, TEHRAN
 
Abstract: 
Background: Diabetes mellitus in some clinical cases is accompanied with hyperalgesia. In this study, we evaluated the possible beneficial effect of chronic pelargonidin (PG) treatment on hyperalgesia in streptozotocin (STZ) -diabetic neuropathic rat.
Methods: Male Wistar rats (n=56) were divided into seven groups, i.e. control, diabetic, PG-treated control, PG (single- and multiple-dose) -treated diabetic, and sodium salicylate-treated control and diabetics. For induction of diabetes, STZ was injected i.p. at a single dose of 60 mg/kg. PG was orally administered at a dose of 10 mg/kg once and/or on alternate days for 8 weeks; 1 week after diabetes induction. After two months, hyperalgesia was assessed using standard formalin and hot tail immersion tests. Meanwhile, markers of oxidative stress in brain were measured. One-way analysis of variance was used for statistical analysis of the data.
Results: Diabetic rats showed a marked chemical and thermal hyperalgesia, indicating that development of diabetic neuropathy and PG treatment (especially multiple-doses) significantly ameliorated the alteration in hyperalgesia (P<0.05-0.01) in diabetic rats as compared to untreated diabetics. PG (multiple doses) also significantly decreased diabetes-induced thiobarbituric acid reactive substances formation and non-significantly reversed elevation of nitrite level and reduction of antioxidant defensive enzyme superoxide dismutase.
Conclusion: These results clearly suggest that PG prevents diabetic neuropathic hyperalgesia through attenuation of oxidative stress.
 
Keyword(s): PELARGONIDIN (PG), STREPTOZOTOCIN (STZ), OXIDATIVE STRESS
 
References: 
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