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Paper Information

Journal:   ANESTHESIOLOGY AND PAIN MEDICINE   FALL 2011 , Volume 1 , Number 2 (2); Page(s) 61 To 65.
 
Paper: 

USE OF REMIFENTANIL AND ALFENTANIL IN ENDOTRACHEAL INTUBATION: A COMPARATIVE STUDY

 
 
Author(s):  IMANI FARNAD*, ALEBOUYEH MAHMOUD REZA, TAGHIPOUR ANVARI ZAHRA, FAIZ SEYYED HAMID REZA
 
* DEPARTMENT OF ANESTHESIOLOGY AND PAIN MEDICINE, RASOUL-AKRAM MEDICAL CENTER, NIYAYESH ST., SATTAR KHAAN AV., TEHRAN, IRAN
 
Abstract: 
Background: Opioids, such as alfentanil, are used to facilitate endotracheal intubation without the use of neuromuscular blocking agents in patients undergoing elective surgery.
Objectives: The goal of this study was to evaluate the endotracheal intubation conditions when remifentanil or alfentanil was used with propofol without the application of neuromuscular blocking agents.
Patients and Methods: One hundred American Society of Anesthesiologists (ASA) grade I patients scheduled for elective surgery were enrolled in this prospective, randomized, triple-blinded study. The patients were randomized to group A (alfentanil) or R (remifentanil). In group A, alfentanil (50 mcg/kg) was intravenously injected over 10 seconds, and after 45 seconds or at the occurrence of apnea, propofol (2 mg/kg) was intravenously injected over 5 seconds. Thirty seconds after the administration of propofol, laryngoscopy and endotracheal intubation were attempted. In group R, remifentanil (5 mcg/kg) was administered instead of alfentanil. Intubation conditions, including ease of laryngoscopy, patency of the vocal cords, jaw relaxation, limb movement (1-4 score), and also, demographic data were evaluated.
Results: There were no demographic data differerences between groups (age, weight, and sex). Further, laryngoscopy, jaw relaxation, and limb movement scores were similar in the R and A groups and there were no significant differences, but vocal cords were significantly more patent in group R than those in group A (P=0.028).
Conclusions: The results of this study showed that remifentanil, similar to alfentanil, provided excellent conditions for endotracheal intubation when used with propofol for the induction of anesthesia; however, remifentanil improved the patency of the vocal cords to a greater extent than alfentanil.
 
Keyword(s): ALFENTANIL, REMIFENTANIL, PROPOFOL, ENDOTRACHEAL INTUBATION
 
 
References: 
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Citations: 
 
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APA: Copy

IMANI, F., & ALEBOUYEH, M., & TAGHIPOUR ANVARI, Z., & FAIZ, S. (2011). USE OF REMIFENTANIL AND ALFENTANIL IN ENDOTRACHEAL INTUBATION: A COMPARATIVE STUDY. ANESTHESIOLOGY AND PAIN MEDICINE, 1(2 (2)), 61-65. https://www.sid.ir/en/journal/ViewPaper.aspx?id=228785



Vancouver: Copy

IMANI FARNAD, ALEBOUYEH MAHMOUD REZA, TAGHIPOUR ANVARI ZAHRA, FAIZ SEYYED HAMID REZA. USE OF REMIFENTANIL AND ALFENTANIL IN ENDOTRACHEAL INTUBATION: A COMPARATIVE STUDY. ANESTHESIOLOGY AND PAIN MEDICINE. 2011 [cited 2021September22];1(2 (2)):61-65. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=228785



IEEE: Copy

IMANI, F., ALEBOUYEH, M., TAGHIPOUR ANVARI, Z., FAIZ, S., 2011. USE OF REMIFENTANIL AND ALFENTANIL IN ENDOTRACHEAL INTUBATION: A COMPARATIVE STUDY. ANESTHESIOLOGY AND PAIN MEDICINE, [online] 1(2 (2)), pp.61-65. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=228785.



 
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