| Abstract:
Research concerning the effects of exercise of human immune
system has revealed contradictory results. It has been shown that, in
general, moderate and regular exercise increases some aspects of
immune systems functions in contrast to intensive exercise, which
can result in inflammatory responses of the immunological system
and acute or chronic inflammation of muscular system in athletes.
The aim of this study was to evaluate the effects of eccentric &
concentric exercises on T-Iymphocyte sub-populations and IL-6
concentration in female athletes.
12 female athletes (mean age 21 ± 0.75 years old, weight
57 ± 5.34 kg, and height 162 ± 2.71 cm, respectively) were
selected to participate in this study.
Subjects performed 13 minutes of eccentric exercise with pacing
on treadmill according to Ellestad protocol and 13 minutes
concentric exercise with pacing on treadmill in opposite direction.
Blood samples were collected before, immediately after, one and two
hours after exercise. Absolute numbers of T lymphocyte sub -
populations including CD4+, CD8+, CD3+, CD56+ (NKC) and
the ratio of CD4+/ CD8+ were determined in blood samples using
flowcytometrey and IL-6 concentration was determined using
ELISA. The results showed that absolute numbers of CD4+, CD3+,
CD8+, CD56+ (NKC) increased significantly immediately after
exercise and decreased significantly after one hour compared to the
resting status levels.IL-6 concentrations showed significant increase
after eccentric exercise.
The results indicated that short term but heavy exercise can
temporary suppress the immune system. This effect will increase
individual susceptibility to pathogens in long term.
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