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Paper Information

Journal:   OLYMPIC   SPRING 2010 , Volume 18 , Number 1 (SERIAL 49); Page(s) 7 To 18.
 
Paper: 

EFFECTS OF SHORT-TERM AND LONG-TERM OF AEROBIC CONTINUOUS TRAINING ON NOVEL AND TRADITIONAL CARDIOVASCULAR BIOMARKERS IN MALE WISTAR RATS

 
 
Author(s):  MOGHARNASI M.*
 
* UNIVERSITY OF SISTAN AND BALUCHESTAN
 
Abstract: 

Scientific evidences indicate that cellular adhesion molecules and inflammatory mediators leading to increase in vascular endothelial activity and introduced as novel inflammatory markers are more sensitive than traditional markers in anticipating cardiovascular diseases, and they have an important role in atherosclerosis pathogenesis. The purpose of this study was to assess the effects of short-term (1 session) and long-term (24&36 sessions) of aerobic continuous training on novel and traditional cardiovascular markers in male wistar rats.36 male rats (3 months old) of wistar race were divided randomly into two groups: Experimental group (n=18 & weight=202±11 gr) and Control group (n=18 & weight=201±12 gr). The training program was performed for 12 weeks, 3 session a week, with the intensity of V02max 55-85% (equivalent to 15-30 m/min) and certain duration 15-60 min. The blood samplings were draw after 14 hours fasting in the similar conditions in three phases of training. The quantity of sICAM-l was measured using the commercial Elisa kit of R&D, and the quantity of IL-1b & TNF-a was measured using the commercial Elisa kits KOMA. The quantity of TC,TG, HDL-C&LDL-C in plasma was measured using Pars Azemoon kits. Data were analyzed using repeated measure, Post Hoc tests of least significant difference (LSD) and t test. The result showed that I session aerobic training did not change significantly the quantity of cardiovascular markers. After 24 sessions of aerobic training, the quantity of sICAM-l (p=0.179), IL-lb (p=0.072) & TNF-a (p=0.163), TC (p=0.059), TG (p=0.340) & LDL-C (p=0.591) decreased insignificantly, whereas, only the quantity of HDL-C (p=0.035) increased significantly. But continuing the training to 36 sessions, the quantity of sICAM-l (p=0.001), IL-lb (p=0.002) & TNF-a (p=0.016), TC (p=0.00l), TG (p=0.024) & LDL-C (p=0.031) decreased significantly. At the end of the study, inter-group significantly difference was observed in the quantity of slCAM-l (p=0.00l), IL-lb (p=0.039), TNF-a (p=0.028), TC (p=0.000), TG (p=0.00l), LDL-C (p=0.000) & HDL-C (p=0.002).Findings of this study showed that aerobic continuous training with increase of: HDL-C and reduction of traditional cardiovascular markers (TC, TG, LDL-C) and novel cardiovascular markers sICAM-I, IL-lb and TNF-a, can immunize individuals against cardiovascular diseases risk and probably they have an important role in preventing and control from cardiovascular diseases.

 
Keyword(s): AEROBIC CONTINUOUS TRAINING, CAMS, INFLAMMATORY MEDIATORS, LIPID PROFILES, RAT
 
References: 
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