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Paper Information

Journal:   PHARMACEUTICAL SCIENCES   2010 , Volume 16 , Number 3; Page(s) 157 To 168.
 
Paper: 

Antinociceptive Effect Of Ascorbic Acid And Involvement Of Nitric Oxide In A Chronic Pain Model

 
 
Author(s):  Nasirinezhad F.*, Safarpour S.
 
* PHYSIOLOGICAL RESEARCH CENTER, PHYSIOLOGY DEPARTMENT, IRAN UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 
Objectives: Ascorbate which is presented in high concentration in nervous system, inhibit nitric oxide synthase enzyme (NOS). We investigated the involvement of NO pathway in the analgesic effects of ascorbic acid (AA) in CCI model of neuropathic rats.Methods: In this experimental study, neuropathic pain is induced by 4 loose ligature around sciatic nerve on left paw of male rats using 4.0 chromic gut (CCI model). Ascorbic acid (1, 5 or 10 mg/kg) or saline was injected intraperituneally two weeks after CCI. Heat and mechanical hyperalgesia and mechanical allodynia were investigated 15 and 30 min after injection. To investigate the involvement of NO on antinociceptive effect of AA on the second week after CCI, 30 min after injection of saline or AA, animals received intraperitunealy injection of L-arginin (500 mg/kg), or L-NAME (20mg/kg) and were tested 20 min after on.Results: Acute injection of 5 and 10 mg/kg but not 1 mg/kg of AA increased pain threshold in the second week after CCI. Injection of 5 mg/kg AA inhibited the nociceptive effect of L-arginin and potentiates the antinociceptive effect of L-NAME and pain threshold was significantly different in these two groups comparing the animals which received normal saline instead of AA.Conclusion: Injection of AA increase pain threshold after nerve injury. Antinociceptive effect of ascorbic acid is dose dependant and that seems to be mediated at least partially via NO pathway.
 
Keyword(s): ASCORBIC ACID, NITRIC OXIDE, NEUROPATHIC PAIN
 
 
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APA: Copy

NASIRINEZHAD, F., & SAFARPOUR, S. (2010). ANTINOCICEPTIVE EFFECT OF ASCORBIC ACID AND INVOLVEMENT OF NITRIC OXIDE IN A CHRONIC PAIN MODEL. PHARMACEUTICAL SCIENCES, 16(3), 157-168. https://www.sid.ir/en/journal/ViewPaper.aspx?id=211507



Vancouver: Copy

NASIRINEZHAD F., SAFARPOUR S.. ANTINOCICEPTIVE EFFECT OF ASCORBIC ACID AND INVOLVEMENT OF NITRIC OXIDE IN A CHRONIC PAIN MODEL. PHARMACEUTICAL SCIENCES. 2010 [cited 2022January25];16(3):157-168. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=211507



IEEE: Copy

NASIRINEZHAD, F., SAFARPOUR, S., 2010. ANTINOCICEPTIVE EFFECT OF ASCORBIC ACID AND INVOLVEMENT OF NITRIC OXIDE IN A CHRONIC PAIN MODEL. PHARMACEUTICAL SCIENCES, [online] 16(3), pp.157-168. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=211507.



 
 
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