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Paper Information

Journal:   JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY)   WINTER 2011 , Volume 20 , Number 78/1 (BIOLOGY ISSU); Page(s) 61 To 70.
 
Paper: 

ANTINOCICEPTIVE EFFECTS OF ETHANOLIC EXTRACT OF SALVIA SCLAREA L. AERIAL PARTS IN MICE

 
 
Author(s):  EIDI A.*, EIDI M., MAZOOJI A., MORTEZAIE S.
 
* BIOLOGY DEPARTMENT, SCIENCE AND RESEARCH BRANCH, ISLAMIC AZAD UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Introduction: The aerial parts of Salvia sclarea L. (Lamiaceae) are cultivated in many European countries for medicinal and cosmetic purposes.
Aim: To determine the antinociceptive effects of Salvia sclarea aerial parts, we investigated the effects of ethanolic extract of the plant in mice.
Material and Method: Antinociceptive activity was done using formalin and writhing tests. The ethanolic extract (10, 50 and 100 mg/kg) were injected intraperitoneally. The control groups were administered saline as vehicle of ethanolic extract.
Results: The results showed that the ethanolic extract of plant decreased both phases of pain in formalin test. The ethanolic extract exhibited antinociceptive activity against acetic acid induced writhing.
Conclusion: The present data indicates that Salvia sclarea aerial parts have analgesic effect on mice and the plant should be considered in future therapeutic researches.

 
Keyword(s): SALVIA SCLAREA, MEDICINAL PLANT, PAIN, MICE
 
References: 
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