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Paper Information

Journal:   OFOGH-E-DANESH   SPRING 2011 , Volume 17 , Number 2 (51); Page(s) 12 To 19.
 
Paper: 

INVESTIGATION OF ANTINOCICEPTIVE AND ANTI-INFLAMMATORY EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF SECURIGERA SECURIDACA L.

 
 
Author(s):  HOODGAR F., NASRI S.*, AMIN GH.R.
 
* DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, PAYAM-E NOOR UNIVERSITY OF TEHRAN, TEHRAN, IRAN
 
Abstract: 

Background and Aim: The application of herbal plants instead of synthetic drugs is increasing in recent years because of their lower side-effects and high varieties of efficient components. The study of anti-inflammatory and antinociceptive effects of hydroalcoholic extract of Securigera securidaca L. seems to be necessary due to the existence of its anti-inflammatory and antinociceptive components.
Materials and Methods: This study has been done on 156 NMRI male mice of 20-25 g in weight. After determining Lethal dose (LD50) of the extract, we used Xylene-induced ear edema and Formalin Test for demonstrating its anti-inflammatory and antinociceptive effects. In each of these two tests, the animals were divided into 6 groups (each group consisting of 8 mice): Sham, Positive Control (receiving dexamethasone at dose of 15 mg/kg in inflammatory test, and receiving morphine at dose of 10 mg/kg in formalin test), experimental groups receiving hydroalchoholic extract at doses of 42, 85, 170 and 340 mg/kg.
Results: LD50 was obtained 1.7 gr/kg. This study shows that the seed of Securigera securidaca L. has anti-inflammatory effect at all doses, particularly at dose of 340 mg/kg. In addition, the extract decreased nociception meaningfully in both acute and chronic phases. Dose of 340 mg/kg had the most antinociceptive effect especially in chronic phase.
Conclusion: The hydroalcoholic extract of Securigera securidaca L. has antinociceptive and anti-inflammatory effect in both phases (especially inflammatory phase) which is caused by formalin, and this effect may be flavonoid and tannin components in plants, which have anti-inflammation and antinociceptive properties. Flavonoid and tannin components in this plant may be the reason of these effects.

 
Keyword(s): ANTI-INFLAMMATION, ANTI-NOCICEPTION, LETHAL DOSE, MALE MICE, SEED OF SECURIGERA SECURIDACA
 
 
References: 
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Cite:
APA: Copy

HOODGAR, F., & NASRI, S., & AMIN, G. (2011). INVESTIGATION OF ANTINOCICEPTIVE AND ANTI-INFLAMMATORY EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF SECURIGERA SECURIDACA L.. OFOGH-E-DANESH, 17(2 (51)), 12-19. https://www.sid.ir/en/journal/ViewPaper.aspx?id=196796



Vancouver: Copy

HOODGAR F., NASRI S., AMIN GH.R.. INVESTIGATION OF ANTINOCICEPTIVE AND ANTI-INFLAMMATORY EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF SECURIGERA SECURIDACA L.. OFOGH-E-DANESH. 2011 [cited 2021April20];17(2 (51)):12-19. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=196796



IEEE: Copy

HOODGAR, F., NASRI, S., AMIN, G., 2011. INVESTIGATION OF ANTINOCICEPTIVE AND ANTI-INFLAMMATORY EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF SECURIGERA SECURIDACA L.. OFOGH-E-DANESH, [online] 17(2 (51)), pp.12-19. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=196796.



 
 
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