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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   JULY 2010 , Volume 13 , Number 4; Page(s) 282 To 287.
 
Paper: 

DISTRIBUTIONS AND ANTIFUNGAL SUSCEPTIBILITY OF CANDIDA SPECIES FROM MUCOSAL SITES IN HIV POSITIVE PATIENTS

 
DOI: 

010134/AIM.006

 
Author(s):  BADIEI PARISA*, ALBORZI A.A.V., DAVARPANAH M.A., SHAKIBA E.
 
* ALBORZI CLINICAL MICROBIOLOGY RESEARCH CENTER, NEMAZI HOSPITAL, ZAND AVE., SHIRAZ 7193711351, IRAN
 
Abstract: 

Background: Mucocutaneous candidiasis (almost endogenous) is one of the most common manifestations of human immunodeficiency virus (HIV) infection. The aim of this study was the investigation of colonization patterns of Candida species, particularly C. dubliniensis, among mucosal sites of HIV-positive patients and determining corresponding in vitro susceptibility patterns to the antifungals.
Methods: From July 2006 to May 2008, specimens from the mucosal sites of 273 seropositive HIV patients were collected for Candida colonization. All isolates were identified by standard methods and carbohydrate assimilation patterns. Isolates phenotypically identified as C. albicans or C. dubliniensis were subjected to molecular identification. Susceptibility patterns of the isolated species to seven antifungal agents were determined using the broth microdilution method.
Results: The 359 samples from mucosal sites which consisted of 273 oral and 86 vaginal were collected and evaluated for Candida species distributions and their corresponding susceptibility patterns. The most commonly isolated species were: C. albicans (50%) followed by C. glabrata (21.4%), C. dubliniensis (13.3%, reported for the first time in Iran), C. krusei (9.8%), C. kefyr (3.1%), C. parapsilosis (1.6%), and C. tropicalis (0.8%). All species were sensitive to amphotencin B, ketoconazole, nystatin, voriconazole, and caspofungin. In some isolates, resistance to fluconazole and itraconazole was noted.
Conclusion: As demonstrated, resistance to fluconazole and itraconazole, the most frequent antifungals in use in the region suggests regular investigation into antifungal resistance in medical centers should be undertaken in order to promote the effective management of invasive candidiasis in HIV/AIDS patients.

 
Keyword(s): C. ALBICANS, C. DUBLINIENSIS, FLUCONAZOLE, MUCOCUTANEOUS CANDIDIASIS
 
 
References: 
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Cite:
APA: Copy

BADIEI, P., & ALBORZI, A., & DAVARPANAH, M., & SHAKIBA, E. (2010). DISTRIBUTIONS AND ANTIFUNGAL SUSCEPTIBILITY OF CANDIDA SPECIES FROM MUCOSAL SITES IN HIV POSITIVE PATIENTS. ARCHIVES OF IRANIAN MEDICINE, 13(4), 282-287. https://www.sid.ir/en/journal/ViewPaper.aspx?id=175503



Vancouver: Copy

BADIEI PARISA, ALBORZI A.A.V., DAVARPANAH M.A., SHAKIBA E.. DISTRIBUTIONS AND ANTIFUNGAL SUSCEPTIBILITY OF CANDIDA SPECIES FROM MUCOSAL SITES IN HIV POSITIVE PATIENTS. ARCHIVES OF IRANIAN MEDICINE. 2010 [cited 2021April18];13(4):282-287. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=175503



IEEE: Copy

BADIEI, P., ALBORZI, A., DAVARPANAH, M., SHAKIBA, E., 2010. DISTRIBUTIONS AND ANTIFUNGAL SUSCEPTIBILITY OF CANDIDA SPECIES FROM MUCOSAL SITES IN HIV POSITIVE PATIENTS. ARCHIVES OF IRANIAN MEDICINE, [online] 13(4), pp.282-287. Available at: <https://www.sid.ir/en/journal/ViewPaper.aspx?id=175503>.



 
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