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Paper Information

Journal:   JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)   SUMMER 2008 , Volume 8 , Number 2 (28); Page(s) 117 To 126.
 
Paper: 

EFFECT OF LOSARTAN AND ENALAPRIL ON ACUTE PHASE REEACTANT (CPR) AND TOTAL ANTI-OXIDANT IN RENAL TRANSPLANT RECIPIENTS WITH RENIN-ANGIOTENSIN SYSTEM POLYMORPHISMS

 
 
Author(s):  AGHAEI SHAHSAVARI M.*, NOUROUZIAN AVAL M., VEYSI P., ARGANI H., RASHTCHIZADEH N., GHORBANI HAGHJOU A., ABEDI AZAR S., VATANKHAH A.M.
 
* DRUG APPLIED RESEARCH CENTER (DARC) OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Background & Objective: As renin-angiotensin system (RAS) activity could affect the severity of oxidative stress and inflammatory markers; the effect of enalapril and losartan on these markers in renal transplant recipients (RTRs) with RAS polymorphisms was assessed.
Methods: After determination of RAS genotypes including angiotensin converting enzyme. (ACE I/D), Angiotensinogen (AGT M235T) and angiotensin II type I receptor (ATRI A1166C) by PCR, seventy-six RTRs recruited to four groups randomly: first group (17 patients) and second group (24 patients) were treated with E (E+: 10mg/daily) and L (L+: 50mg/daily) alone, respectively. The third group (17 patients as positive control) received E+L (E+L+: 10mg/daily + 50mg/daily) and the 4th group (18 patients as negative control) received no medication (E-L-).Hs-CRP and total anti-oxidant (TA) as inflammatory and anti-oxidative markers were measured after 2 months. After 2 weeks as washout period, E group changed to L and vice versa as a cross-over design. They were followed for another 8 weeks and hs-CRP and TA were retested.
Results: Following up the patients (after 2,4 months of treatment) in treated groups revealed that hs-CRP and TA levels were significantly decreased and increased (consequently) in E+L+, L+, E+ groups (P<0.05). On analyzing the relationship between RAS polymorphisms with baseline hs-CRP and TA levels, CC genotype of ATRI had lower hs-CRP levels (P=0.04). But none of the RAS polymorphisms could predict the anti-oxidative and anti-inflammatory response rate to the drugs (P>0.05).
Conclusion: E and/or L reduce hs-CRP and increase TA regardless of the RAS genotypes.

 
Keyword(s): ENALAPRIL, LOSARTAN, RAS POLYMORPHISMS, ACUTE PHASE REACTANT (CPR), TOTAL ANTI OXIDANT, RENAL TRANSPLANTATION
 
References: 
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