This study examined the relationships among five constructs: Neuroticism, coping styles, academic stressors, reactions to stressors and subjective well-being among 419 university students (166 males 235 females). Structural equation modeling was used to assess the relationships among the latent and measured variables in the conceptual model. Results indicated that higher levels of subjective well-being were predicted by lower scores of neuroticism factor, higher scores of task oriented coping style- and conversely scores of emotion oriented coping style –and lower levels of academic stressors and reactions to stressors. Results also indicated that the relationships between neuroticism, academic stressors, reactions to stressors and subjective well-being were mediated by task and emotion oriented coping styles; the relationship between neuroticism and reactions to stressors was mediated by academic stressors; and the relationship between neuroticism and well-being was mediated by reactions to stressors. Higher academic stressors predicted grater reactions to strssors and lower scores of well-being. All of the regression weights in the model were statistically significant, and the model's predictors accounted for %35 of the variance in subjective well-being.