Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JOURNAL OF MEDICINAL PLANTS   MARCH 2009 , Volume 8 , Number 29; Page(s) 123 To 130.
 
Paper: 

EFFECT OF ORAL (SYSTEMIC) ELAEAGNUS ANGUSTIFOLIA L. FRUIT ON STIMULATED GASTRIC ACID SECRETION IN UNCONSCIOUS RAT AND ON BASAL ACID SECRETION IN CONSCIOUS RAT

 
 
Author(s):  ELIASI AFSANEH*, GHODRATI M., KAMALINEZHAD MOHAMMAD
 
* NEUROSCIENCE RESEARCH CENTER AND DEPARTMENT OF PHYSIOLOGY, FACULTY OF MEDICINE, SHAHID BEHESHTI UNIVERSITY (M.C.), TEHRAN, IRAN
 
Abstract: 

Background: It has been clearly documented that Elaeagnus angustifolia (E.A.) have variety of medicinal uses including anti - ulcerogenic activity. Our recent study demonstrates that intragastric administration of E.A. blocked the carbachol - induced gastric acid secretion, completely.
Objective: The aim of this work therefore is to evaluate the role of oral administration of E.A. on carbachol - induced gastric acid secretion in order to compare with intragastric effect of the drug. We also hypothesized that E.A. fruit might be involved in control of basal acid secretion and juice volume. To address this question, we investigated the oral effect of E.A. fruit extract on basal acid secretion on pylorous - ligated conscious rats.
Methods: In this study we used pylorus ligation method. Briefly, animals were anesthetized and two cannulas were introduced into the stomach through esophagus to wash the stomach and pylorousdodenal junction to collect the stomach juice. Carbachol was infused into jugular vein and gastric juice was collected in 10 - min periods to titrate with NaOH 0.01 N.
To concider the effect of the E.A. extraction on basal acid secretion, all experiments were performed in conscious rats who received the E.A. extract or saline 1.5 hours before pylorus-ligation. Ligation of pylorus was performed under brief ether anesthetized. Two and half hours after treatment, the stomach was removed, juice volume was measured and acid output was determined as above. Statistical analysis was performed by analysis of variance and subsequent tukey test.
Results: Our results showed that the E.A. fruit extract dose dependently decreased the carbachol - induced gastric acid secretion. Stimulated acid secretion was suppressed %52 ± 4 at a dose 600 mg/kg and this inhibitory effect persisted up to the end of experiments.
Oral administration of E.A. extraction in pylorus ligated conscious rats showed that the drug significantly stimulated gastric acid secretion and juice volume at a dose 1300 mg/kg within 1 hour, but there was no effect at lower doses.
Conclusion: These results suggest that E.A. fruit has an anti-secretory action on cholinergic stimulated acid secretion by oral administration. This effect is less than the intragastric administration of the drug (% 81±4 inhibition). It is likely that the inhibitory effect is mediated by cholinergic nervous system and/or non-neuronal membranes.
We also suggest that the oral E.A. extract has no effect on basal acid secretion at lower doses.

 
Keyword(s): GSTRIC ACID, TADITIONAL MEDICINE, ELAEANGUS ANGUSTIFOLIA, PLORUS-LIGATION METHOD
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 64
 
Latest on Blog
Enter SID Blog