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Paper Information

Journal:   IRANIAN JOURNAL OF MEDICAL PHYSICS   FALL 2008-WINTER 2009 , Volume 5 , Number 2 (20-21); Page(s) 39 To 51.
 
Paper: 

TREATMENT OF COLON CARCINOMA TUMORS BY ELECTROLYSIS: EFFECT OF ELECTRICAL DOSE AND POLARITY

 
 
Author(s):  SAZGARNIA A.*, BAHREYNI TOUSI SEYED MOHAMMAD HOSSEIN, SHIRIN SHANDIZ M., BAYANI ROUDI SH., KHOUEI ALI REZA, ESMAEILI HABIB ELAH, HOMAEI SHANDIZ FATEMEH
 
* MEDICAL PHYSICS DEPT., MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 
Introduction: As a physical treatment, electrochemical therapy (ECHT) has provided an effective and useful approach for treating localized tumors. The chemical changes due to a direct electric current destroy the tumor. This study evaluates the effect of electrical dose and polarity on the efficacy of the treatment of a colon tumor model.Materials and Methods: In order to induce tumors, 5´ 105 CT26 cells were injected into the right dorsal side of 100 Balb/c mice subcutaneously. When the mean volume of the tumors reached 350±50 mm3, they were randomly divided into 2 control and 8 test groups, each consisting of 10 mice. Six platinum electrodes (3 cathodes and 3 anodes) were inserted into the base and the apex of each tumor. Electrical doses of 0, 10, 20, 30 or 40 C/cm3 were then applied. Tumors volumes were subsequently measured daily and the mortalities were recorded. A histopatholological study was also performed.Results: After ECHT, a decrease in tumor volume and also an increase in necrosis and cumulative survival were statistically significant. In the control groups, the tumors were not destroyed and the mice did not survive more than 50 days. With 40 C/cm3 electrical dosage and anode electrode polarity applied to bases of the tumors, 80% of the tumors showed complete response until 120 days post-treatment. Increasing the electrical dose caused a statistically significant effect on the complete response percentage and the cumulative survival fraction. Applying anode polarity to the bases of the tumors produced better results although without statistical significance.Discussions and Conclusions: Complete response in the treatment groups (10 to 80 percent) demonstrates the antitumor effects and the high potential of electrolysis for tumors eradication. Also, occurrence of only one death event in the highest electrical dose group and the good health of the animals until 120 days after treatment demonstrate that electrolysis is a safe technique.
 
Keyword(s): ELECTROLYSIS, ELECTRICAL DOSE, POLARITY, ELECTRODES CONFIGURATION, MICE COLON CARCINOMA, CT26 CELL LINE
 
 
References: 
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APA: Copy

SAZGARNIA, A., & BAHREYNI TOUSI, S., & SHIRIN SHANDIZ, M., & BAYANI ROUDI, S., & KHOUEI, A., & ESMAEILI, H., & HOMAEI SHANDIZ, F. (2009). TREATMENT OF COLON CARCINOMA TUMORS BY ELECTROLYSIS: EFFECT OF ELECTRICAL DOSE AND POLARITY. IRANIAN JOURNAL OF MEDICAL PHYSICS, 5(2 (20-21)), 39-51. https://www.sid.ir/en/journal/ViewPaper.aspx?id=139715



Vancouver: Copy

SAZGARNIA A., BAHREYNI TOUSI SEYED MOHAMMAD HOSSEIN, SHIRIN SHANDIZ M., BAYANI ROUDI SH., KHOUEI ALI REZA, ESMAEILI HABIB ELAH, HOMAEI SHANDIZ FATEMEH. TREATMENT OF COLON CARCINOMA TUMORS BY ELECTROLYSIS: EFFECT OF ELECTRICAL DOSE AND POLARITY. IRANIAN JOURNAL OF MEDICAL PHYSICS. 2009 [cited 2021December07];5(2 (20-21)):39-51. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=139715



IEEE: Copy

SAZGARNIA, A., BAHREYNI TOUSI, S., SHIRIN SHANDIZ, M., BAYANI ROUDI, S., KHOUEI, A., ESMAEILI, H., HOMAEI SHANDIZ, F., 2009. TREATMENT OF COLON CARCINOMA TUMORS BY ELECTROLYSIS: EFFECT OF ELECTRICAL DOSE AND POLARITY. IRANIAN JOURNAL OF MEDICAL PHYSICS, [online] 5(2 (20-21)), pp.39-51. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=139715.



 
 
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