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Paper Information

Journal:   TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)   2004 , Volume 62 , Number 6; Page(s) 475 To 480.
 
Paper: 

THE PROTECTIVE EFFECT OF VITIS VINIFERA IN HEPATOTOXICITY INDUCED BY TOXIC DOSE OF ACETAMINOPHEN IN MICE

 
 
Author(s):  KALANTARI H.A., SEDIGH N.
 
* 
 
Abstract: 

Background: The use and application of medicinal plants or herbal medicine in therapy is well known. In this investigation aim was to determine the hepato protective effect of hydroalcoholic extract of Vitis Vinifera as a crude extract in hepatotoxicity induced by toxic dose of acetaminophen in mice. Materials and Methods: In this study doses of 160, 180,200,220, 240, and 260 mg/kg were administered to mice orally (test groups). The positive group received toxic dose of acetaminophen (500 mg/kg) and the negative control group received normal saline.
Results: Then sleeping time, enzyme activities such as SGOT and SGPT and histo-pathological examinations were measured. The results obtained in this study showed a significant protection as compared with the control group because the level of SGOT and SGPT as well as sleeping time and histo-pathological findings were mostly similar to the results of control group.
Conclusion: From these observations it seems that this crude extract may be a good candidate in liver toxicity after purification and separation of active ingredient.

 
Keyword(s): VITIS VINIFERA, ACETAMINOPHEN, HEPATOTOXICITY, HERBAL MEDICINE
 
 
References: 
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Citations: 
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APA: Copy

KALANTARI, H., & SEDIGH, N. (2004). THE PROTECTIVE EFFECT OF VITIS VINIFERA IN HEPATOTOXICITY INDUCED BY TOXIC DOSE OF ACETAMINOPHEN IN MICE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 62(6), 475-480. https://www.sid.ir/en/journal/ViewPaper.aspx?id=13392



Vancouver: Copy

KALANTARI H.A., SEDIGH N.. THE PROTECTIVE EFFECT OF VITIS VINIFERA IN HEPATOTOXICITY INDUCED BY TOXIC DOSE OF ACETAMINOPHEN IN MICE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ). 2004 [cited 2021October20];62(6):475-480. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=13392



IEEE: Copy

KALANTARI, H., SEDIGH, N., 2004. THE PROTECTIVE EFFECT OF VITIS VINIFERA IN HEPATOTOXICITY INDUCED BY TOXIC DOSE OF ACETAMINOPHEN IN MICE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), [online] 62(6), pp.475-480. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=13392.



 
 
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