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Paper Information

Journal:   JOURNAL OF MEDICAL COUNCIL OF I.R.I.   Spring 2003 , Volume 21 , Number 1; Page(s) 51 To 54.
 
Paper: 

THE IMPORTANCE OF PRECISE MEASUREMENT OF HBF IN THE DIFFERENTIAL DIAGNOSIS OF SICKLE CELL ANEMIA FROM SICKLE BETA THALASSEMIA

 
 
Author(s):  POURFATH ELAH A.A., RAHGOZAR S., MOAFI A.R.
 
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Abstract: 

Sickle cell anemia, in heterozygous form, although appears to have a high incidence in Iran, particularly in the Southern provinces; unfortunately has not received the right attention and thus creating screening and prevention problems for haemoglobin disorders. Because of, laboratory and clinical similarities between, Indian Arad haplotype of sickle cell anemia which is estimated to have a high incidence in Iran, and, sickle beta talassaemina which is more frequent in this country, might cause diagnostic problems.
In this article we present three cases with sickle cell anemia wich were diagnosed as sickle beta halassaemia. Eventually, we suggest determining haematological indices of patients parents and measuring HbF in suspected patients precisely by alkali denaturation, after the patient haemoglobin electrophoresis, to reduce incorrect diagnosis.

 
Keyword(s): SICKLE CELL ANEMIA, SICKLE BETA THALASSEMIA, FETAL HEMOGLOBIN (HBF)
 
References: 
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  Persian Abstract Yearly Visit 61
 
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