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Paper Information

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   Spring 2001 , Volume 8 , Number 1 (SN 19); Page(s) 9 To 14.
 
Paper: 

COMPARATIVE STUDY OF EVALUATION OF THERAPEUTIC EFFECTS OF THE THYME C.W, SAVORY C.W. DROPS AND THYME MIXTURE C.W. WITH RANITIDINE - METOCLOPRAMIDE COMPOUND IN FUNCTIONAL DYSPEPSIA

 
 
Author(s):  MOHAMMADALIZADEH A.H.*, MANI KASHANI KH., SHARAFI N., NAJAFIAN M.
 
* Department of Internal medicine, School of Medicine, Hamadan University of Medical Sciences & Health Services, Hamadan, Iran
 
Abstract: 

Functional dyspepsia found in 25% of the general population and a large number of patients referred to the health centers. Treatment of this disease with promotility drugs is not effective, and is so expensive too. Evaluation of therapeutic effects of the thyme C.W, savory C.W. drops and thyme mixture in comparison with ranitidine - metoclopramide compound is the aim of this study.
This is a randomized clinical trial study in 180 patients with dyspepsia selected in sequential sampling with similar diet, age group and the same smoking habit. They were randomly divided into four therapeutic groups; the whole groups except to the fourth group used thyme C.W, savory C.W. drops and thyme mixture C.W. with ten drops in three times a day during a month in a double blind method. The fourth group used ranitidine metoclopramide compound during a month with the following orders: 1- One tablet ranitidine every 12 hours 2- One tablet metoclopramide every 8 hours. It is necessary to be mentioned that biopsy urease test (BUT) and histology for evaluation of helicobacter pylori were performed in each group and each group was divided in two subgroups that include: HP. Positive and HP. Negative.
This study indicated that C.W. drop, savory C.W. drop, thyme mixture drop and ranitidine - metoclopramide compound caused disappearance of 75% (or more)of symptoms of disease (the complete healing) in 55.6% , 53.3% , 42.2% and 42.2% of patients respectively.
Thyme C.W, and savory C.W. drops had the similar therapeutic effects with that of ranitidine metoclopramide compound in the patients with functional dyspepsia. Thyme mixture C.W. had a similar therapeutic effect with ranitidine - metoclopramide compound. Urease positive patients gave more response especially with the thyme C.W. drop group.

 
Keyword(s): FUNCTIONAL DYSPEPSIA - DRUG THERAPY, METOCLOPRAMIDE, PLANT THERAPY, RANITIDINE
 
References: 
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