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Paper Information

Journal:   SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES   SUMMER 2008 , Volume 13 , Number 2 (SERIAL NUMBER 48); Page(s) 69 To 75.
 
Paper: 

EVALUATION OF ISCHEMIA TOLERANCE IN THE RABBIT HEART ISOLATED BEFORE MATURATION

 
 
Author(s):  GOUDINI A.A.*, SHAKIBAEI D.
 
* MEDICAL BIOLOGY RESEARCH CENTER, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH IRAN
 
Abstract: 

Background and Aim: Several studies have shown that cardiac tolerance of ischemia, before maturation is greater in the newborn than adults and it decreases gradually in the rest of life. Most studies on cardiac tolerance before maturation have shown this tolerance gradually decreases before maturation. But a few studies have not confirmed such results. In regard to its clinical importance this study was designed to determine the change in the pattern of tolerance of ischemia before maturation.
Material and Methods: Hearts of 2, 3, 6 and 8 week-old rabbits were isolated and per fused under constant pressure according to langendorff method. Coronary flow (CF) and functional parameters including heart rate (HR) and fluctuations in the left ventricular developed pressure (LVDP) were measured and the product of (HR x LVDP) (RPP) was calculated. Steps of the experiment included baseline period (20 min), ischemia (35 min) at temperature of 37
°C and reperfusion for 45 minutes. Cardiac parameters including RPP were evaluated 45 minute after reperfusion and at the baseline period. ANOVA test was used for data analysis.
Results: Recovery of the heart function in 3 week old rabbits (85.81
±4.36) (mean±SE) was significantly greater than those of 2, 6 and 8 week old rabbits (67.57±3.27), (61.19±2.83) and (52.03±5.09) respectively (P<0.05).
Conclusion: It can be concluded that tolerance of ischemia in rabbit before maturation doesn't decrease and reaches its maximum between birth and maturation.

 
Keyword(s): ISOLATED HEART, ISCHEMICTOLERANCE, NEWBORN RABBIT
 
References: 
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