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Paper Information

Journal:   ACTA MEDICA IRANICA   SEPTEMBER-OCTOBER 2008 , Volume 46 , Number 5; Page(s) 353 To 360.
 
Paper: 

EFFECTS OF ISCHEMIA-REPERFUSION ON RAT RENAL TISSUE ANTIOXIDANT SYSTEMS AND LIPID PEROXIDATION

 
 
Author(s):  RASOULIAN B.*, JAFARI M., NOUROUZZADEH A., MEHRANI H., VAHAB AGHAEI H., HASHEMI MADANI S.M.H., GHANI E., ESMAEILI M., ASGARI A., KHOUSHBATEN A.
 
* RAZI HERBAL MEDICINES RESEARCH CENTER AND DEPARTMENT OF PHYSIOLOGY, LORESTAN UNIVERSITY (MEDICAL SCIENCES), KHORRAMABAD, IRAN
 
Abstract: 
Renal ischemia-reperfusion (IR) injury is a common problem in kidney transplantation. There is increasing evidence about the role of the reactive oxygen species (ROS) in these injuries and endogenous antioxidants seem to have an important role in decreasing the renal tissue injury. The aim of this study was to investigate the effects of kidney IR on renal antioxidant enzymes activity such as catalase and superoxide dismutase (SOD) and renal glutathione (GSH) levels. The level of malondialdehyde (MDA), an end product of lipid peroxidation, also was quantified. Male Wister rats (200-280 g) were anesthetized and after right nephrectomy, the left renal artery was clamped for 40 min. After 24 h reperfusion, serum and kidney tissue samples were obtained for metabolites assay. Results showed that renal IR increased serum creatinine and urea level [90.59 ± 12.93 vs. 44.06 ± 4.07 mmol/L (P < 0.01), and 40.22 ± 10.27 vs. 20.8 ± 1.8 mmol/L, (P < 0.05), respectively]. The renal catalase activity was decreased (33.13 ± 2.02 vs. 43.78 ± 2.38 units/mg protein, P < 0.01) but SOD activity was increased (57.59 ± 4.64 vs. 42.84 ± 1.85 units/mg protein, P < 0.05). The GSH level also was decreased (24.67 ± 2.31 vs. 37.44 ± 3.09 nmol/mg protein P < 0.01). MDA level after IR was not significantly different from control group (2.05 ± 0.27 vs. 1.84 ± 0.2 nmol/mg protein, P = 0.55). Our data indicated that despite decrease in renal GSH level and catalase activity following IR, SOD activity was increased.
 
Keyword(s): KIDNEY, ISCHEMIA, REPERFUSION, ANTIOXIDANT, MALONDIALDEHYDE
 
 
References: 
 
Citations: 
 
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APA: Copy

RASOULIAN, B., & JAFARI, M., & NOUROUZZADEH, A., & MEHRANI, H., & VAHAB AGHAEI, H., & HASHEMI MADANI, S., & GHANI, E., & ESMAEILI, M., & ASGARI, A., & KHOUSHBATEN, A. (2008). EFFECTS OF ISCHEMIA-REPERFUSION ON RAT RENAL TISSUE ANTIOXIDANT SYSTEMS AND LIPID PEROXIDATION. ACTA MEDICA IRANICA, 46(5), 353-360. https://www.sid.ir/en/journal/ViewPaper.aspx?id=124975



Vancouver: Copy

RASOULIAN B., JAFARI M., NOUROUZZADEH A., MEHRANI H., VAHAB AGHAEI H., HASHEMI MADANI S.M.H., GHANI E., ESMAEILI M., ASGARI A., KHOUSHBATEN A.. EFFECTS OF ISCHEMIA-REPERFUSION ON RAT RENAL TISSUE ANTIOXIDANT SYSTEMS AND LIPID PEROXIDATION. ACTA MEDICA IRANICA. 2008 [cited 2021December03];46(5):353-360. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=124975



IEEE: Copy

RASOULIAN, B., JAFARI, M., NOUROUZZADEH, A., MEHRANI, H., VAHAB AGHAEI, H., HASHEMI MADANI, S., GHANI, E., ESMAEILI, M., ASGARI, A., KHOUSHBATEN, A., 2008. EFFECTS OF ISCHEMIA-REPERFUSION ON RAT RENAL TISSUE ANTIOXIDANT SYSTEMS AND LIPID PEROXIDATION. ACTA MEDICA IRANICA, [online] 46(5), pp.353-360. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=124975.



 
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