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Paper Information

Journal:   HORMOZGAN MEDICAL JOURNAL   Spring 2003 , Volume 7 , Number 1; Page(s) 21 To 25.
 
Paper: 

SAFETY AND EFFICACY OF PRIMIDONE AND CARBAMAZEPINE IN CHILDHOOD PARTIAL SEIZURE: A RANDOMIZED CLINICAL TRIAL

 
 
Author(s):  MOAIEDI A.R.*, MASOOMI ASL M.
 
* Department of Pediatrics, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
 
Abstract: 

Introduction: Epilepsy is one of the most prominent problems in pediatrics. Statistics show that 5 to 8 persons out of 1000 suffer from seizure disorders, and about 300.000 children in Iran have epilepsy, 40% of whom have partial seizure. This investigation was conducted to study the effectiveness and side effects of primidone, as the standard first line treatment of partial seizure and to compare it with carbamazepine.
Method and Material: In this clinical trial study, 30 patients (<18 years old) including 20 boys and 10 girls, with newly diagnosed and previously untreated partial epileptic seizure from Bandar Abbas childrens hospital were enrolled. Subjects were randomly divided into two equal groups. Carbamazepine 15-25 mg/kg/day and primidone 10-25 mg/kg/day were administered to each of the patients during a 6- months period. Data analysis was performed using paired t-test and p<0.05 was considered as significant.
Results: Mean seizure frequency in carbamazepine group was reduced from 2.5 times to 0.3 during the study period. In the primidone group, this figure reduced from 2 times to 0.07 times. The differences were statistically significant (p<0.05). The mean time of seizure in carbamazepine group was reduced from 5 minutes to 1.6 minutes. In primidone group, the mean time of seizure was reduced from 4.1 minutes to 0.37 minute. These differences were also significant (p<0.05).
Discussion: Primidone and carbamazepine show similar efficacy against partial seizures in newly diagnosed epilepsy in children. Primidone, however, had better effect on EEG outcome. In conclusion, we suggest that after some more extensive studies, primidone can be used as the first choice of therapy for pediatric partial seizure.

 
Keyword(s): CARBAMAZEPINE, EPILEPSY, EPILEPSY, PARTIAL, CHILD
 
References: 
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