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Paper Information

Journal:   PHYSIOLOGY AND PHARMACOLOGY   FALL 2007 , Volume 11 , Number 3; Page(s) 167 To 173.
 
Paper: 

LONG-LASTING EFFECTS OF ORAL MORPHINE DEPENDENCE ON SPATIAL LEARNING AND MEMORY IN RATS

 
 
Author(s):  POURMOTEABED A.R.*, TOUHIDI A., NEDAEI S.E., FARSHCHI B., PEYVASTEGAN N., SAMADZADEH SARA
 
* DEPT. PHYSIOLOGY, SCHOOL OF MEDICINE, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, IRAN
 
Abstract: 
Introduction: It has been previously reported that oral morphine dependence facilitates formation of spatial learning and memory in rats. Therefore, in the current study the long lasting effects of morphine on above mentioned phenomena in with drawn animals were studied.
Methods: In present study N-MRI male rats (250-350 g) received morphine sulfate (0.1- 0.4 mg/m!) (in dependent and withdrawal groups) or sucrose (in control group) in drinking water for 30 consecutive days. Morris water maze (MWM) studies were performed during morphine or sucrose application (in control and dependent animals), or after morphine elimination (in withdrawal groups). Spatial learning and memory parameters were recorded and subjected to the ANOVA.
Results: Data showed better acquisition of spatial learning in dependent and withdrawal groups with respect to control animals.
Conclusion: Oral morphine dependence has long lasting facilitator effect on acquisition of spatial learning in rats.
 
Keyword(s): ORAL DEPENDENCE, RAT, SPATIAL LEARNING AND MEMORY, MORRIS WATER MAZE
 
References: 
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